The book explores the potential of natural remedies for respiratory diseases, focusing on Saussurea costus and polyphenols from medicinal plants in treating COVID-19 and asthma. Key bioactive molecules from Saussurea costus, particularly Cynaropicrin, show promise against COVID-19, supported by molecular dynamics simulations. Additionally, polyphenols like Geraniol and Carvacrol demonstrate potential in managing both SARS-CoV-2 infections and asthma. Integrating traditional medicine with modern science offers promising new treatments for respiratory diseases.