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Justus Freiherr (Baron) von Liebig (born 12 May 1803 - died 18 April 1873) was a renowned German chemist who made significant contributions to inorganic, organic, and agricultural chemistry. Liebig's work at the University of Giessen in Germany led to the development of modern teaching methods based on experimental laboratory-oriented work. This earned him recognition as one of the "greatest chemistry teachers of all time". He is often referred to as the "father of the fertilizer industry" from his seminal contributions on nitrogen and trace minerals as essential plant nutrients. Through these contributions and more, Liebig helped shape the field of inorganic, organic, food, and agricultural chemistry. Thus, it is more than deserved that a Special Issue of Chemistry was dedicated in 2023 to commemorate 150 Years of Justus von Liebig's Legacy. We are happy that 21 colleagues and their coworkers from all areas of chemistry accepted our invitation and contributed to this Special Issue of Chemistry in 2023. Their contributions are now also collected in this Special Issue reprint.