In the last decade physical comorbidity and mental disorder have dramatically increased, with an epidemic proportion in several countries. Comorbidity is increasing exponentially and with negative consequences. The presence of two or more diseases is not as simple as we see it, rather it worsens the prognosis of all the diseases that are present, leading to increase complications, making adherence to treatment difficult especially in the prison environment. It is therefore imperative to recognize the significance of these combination of diseases and as researchers, and clinicians to give specific attention to this group of individuals who are already prone to various diseases/psychosocial issues due to their incarceration.