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Colon cancer is a public health problem. The differentiation between right and left colon cancer is a topical issue. This study investigates the impact of colon cancer location (right or left) on the prognosis of patients after curative surgery. Carried out over a five-year period and including 105 patients, the study shows no significant differences in terms of overall survival and recurrence-free survival between the two groups. However, poor prognostic factors common to both localizations were identified, such as advanced tumor stage and the presence of peri-nerve sheathing. Specific differences were also observed, such as the presence of peritonitis on the right side and lymph node involvement on the left. In addition, epidemiological, clinical and histological variations were noted between the two groups. The study underlines the importance of early detection in improving the prognosis of colon cancer.