Glass Powder (GP) and GGBS are possesses high pozzolanic activities and very suitable as partial replacement of cement in concrete. This paper presents a comparison study between two waste material like Glass Powder and GGBS as partial replacement of cement in concrete specimens. Review of the researches on physical, mechanical and structural properties of concrete containing Glass Powder and GGBS as partial replacement of ordinary Portland cement was included in this paper. Simultaneously, concrete specimens were tested with different percentages of Glass Powder and GGBS as replacement of cement content and with different w/c ratio. Compressive strength, carried out to evaluate the which one is appropriate of using Glass Powder or GGBS in concrete. The replacement of cement by Glass Powder and GGBS both are in structural concrete represents a good alternative in as economical as strength consideration of concrete, even without any kind of processing and found environmental benefits related to the disposal of waste.