The current study is about efficacy of new insecticides like avermectins, chitin synthesis inhibitor and commonly used fugicides alone and its combinations against Tobacco caterpillar - Spodoptera litura and Aspergillus flavus. As most of the pesticides are specifically toxic either to insect pest or disease causing pathogen, management of both with any single pesticide is not practicable. Therefore it is necessary to mix an insecticide with the fungicide and apply on a crop. Application of two or more chemicals can save time, labour, energy and equipment cost provided there are no adverse effects on the plant, non target organisms and on the efficacy of the chemicals in combating the problems.