Computational Methods for Reproductive and Developmental Toxicology

Herausgeber: Mattison, Donald R

• Gebundenes Buch

Produktbeschreibung

Building from the perspective of reproductive and developmental biology, this book provides a timely and comprehensive overview of computational approaches in reproductive and developmental toxicology. It is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next section reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 330
• Erscheinungstermin: 8. Dezember 2015
• Englisch
• Abmessung: 236mm x 155mm x 23mm
• Gewicht: 907g
• ISBN-13: 9781439861073
• ISBN-10: 1439861072
• Artikelnr.: 32960252

Autorenporträt

Edited by Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada

Inhaltsangabe

INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs
of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and
Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES
AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of
Pregnancy. Early Embryo Development and Bipotential Gonad Formation.
Assessing the Reproductive Health of Men with Occupational Exposures.
REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal
Study Protocols and Alternative Assays for the Assessment of Reproductive
and Developmental Toxicity. US National Library of Medicine Resources for
Computational Toxicology. Modeling Endocrine Regulation of the Menstrual
Cycle Using Delay Differential Equations. Molecular Structural
Characteristics That Influence Partitioning of Xenobiotics into Human
Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver
Injury. Adverse Outcome Pathways for Developmental Toxicity.