Computational Protein-Protein Interactions

Herausgeber: Nussinov, Ruth; Schreiber, Gideon

• Gebundenes Buch

Produktbeschreibung

A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for predicting function. The text provides an overview of the topic with general chapters understandable by students and junior researches in this area, while also providing advanced material for more specialized readers. The chapters detail the complexity of protein interaction studies and inform readers of potential caveats that might be involved.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 344
• Erscheinungstermin: 15. Juni 2010
• Englisch
• Abmessung: 240mm x 161mm x 23mm
• Gewicht: 683g
• ISBN-13: 9781420070057
• ISBN-10: 1420070053
• Artikelnr.: 23140435

Autorenporträt

Ruth Nussinov, Gideon Schreiber

Inhaltsangabe

Computational design of protein-protein interactions. Molecular Mimicry and
Competitive Recruitment. Intrinsically unstructured proteins. The molecular
architecture of protein-protein binding sites. Characteristic of
protein-protein recognition. Protein-Protein Docking. Identification of hot
spots within druggable binding regions. Hot-spot mimicry of ac cytokine
receptor. Chaperone-related immune dysfunction. Recognition proteins of the
innate immune system. Epitope mapping using combinatorial phage-display
libraries. Identification of conserved protein complexes based on a model
of protein network evolution. Interaction sites identified from sequences.
Thermophilic Protein Complex Stabilized by Topological Interlinked. Protein
interface recognition for structural proteomics. Strategies to search and
design stabilizers of protein-protein interactions. Dynamics and allostery
in protein-protein interactions.