Computational study on natural products as emerging hope for arthritis - Mukhopadhyay, Rishov
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Osteoarthritis is a progressive challenge to the people of almost all ages nowadays, though initially it threatened only the geriatric group. Specific curative therapies for this ailment is still on a questionable scaffold, where prescribers are mainly relying on providing symptomatic relief to the patients through NSAIDs and even narcotic analgesics in rare but severe cases. The most common treatment horizon has been found to be knee replacement, whose success rate can be widely argued upon. Recent research have found the role of MMP13 in the degeneration of bone cartilage leading to…mehr

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Produktbeschreibung
Osteoarthritis is a progressive challenge to the people of almost all ages nowadays, though initially it threatened only the geriatric group. Specific curative therapies for this ailment is still on a questionable scaffold, where prescribers are mainly relying on providing symptomatic relief to the patients through NSAIDs and even narcotic analgesics in rare but severe cases. The most common treatment horizon has been found to be knee replacement, whose success rate can be widely argued upon. Recent research have found the role of MMP13 in the degeneration of bone cartilage leading to osteoarthritis, where reverse hydroxamate based inhibitors have been found to be promisingly useful to suppress this enzyme. But further studies have identified potential risk from these. Thus, natural molecules are coming up, where selective optimization might produce range of drug like compounds. Computational drug development approach can be handy tool in this domain, where profound understandingof the natural compounds can help us to identify its interactions with target proteins, responsible for diseases. Thus, might be helpful in screening for lead candidates in drug discovery pipeline.
Autorenporträt
An Indian by birth, I have graduated from the University of Nottingham studying MSc in Drug Discovery and Pharmaceutical Sciences. I completed my undergraduate studies in Pharmaceutical Sciences (Bachelor of Pharmacy-Ayu) from Jadavpur University, where I was awarded First class First ¿ Gold Medal in 2014. I have served in FMCG as Q.C. Chemist.