this book explain the role of computational software used by above authorities such as LAZAR to measure carcinogenicity in different species , which gives binary results "Active , In active" , and TEST software (2016 version) to measure the mutagenicity and teratogenicity (Developmental Toxicity) in living organisms . The study screened about 180 chemicals, distributed in general chemicals and drugs. Some of them were carcinogens, mutagens or teratogens, and some had no activities as in benign molecules (Negative control). The highest positive carcinogens were recorded for toxin group (66.7%), the rest were in between.