One of the most important features of mould cooling in injection moulding is the provision of suitable and adequate cooling arrangements. For many years, mould designers and researcher have been trying to improve the performance of cooling system, despite the fact that cooling system complexity is physically limited by fabrication capability of conventional straight drilling methods. This thesis book presents a comprehensive investigation on the application of conformal cooling channels in injection moulding for different cross sectional shapes, positions and diameter by endeavoring which conformal cooling configuration gives the best results in comparison with conventional cooling channels. Mould design with efficient cooling channels, comprehensive finite element analysis and flow simulation have been performed for different plastic parts. Laser direct metal deposition (DMD) rapid manufacturing technology has been used to fabricate conformal cooling channel in injection mould for experimental validation of the results obtained by numerical modeling.