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The book discusses issues related to the peculiarities of collagen metabolism in diabetic patients, the influence of congenital disorders of connective tissue metabolism on the risk of diabetes complications. The authors analyze the peculiarities of congenital and acquired disorders of collagen metabolism in diabetes mellitus and their significance as prognostic factors. Scientific data revealing some mechanisms of "hyperglycemic memory" formation are presented. The prognostic value of some risk factors of the loss of ability to work is evaluated based on the author's methods of evaluating the rehabilitation possibilities of the organism. The book is of interest for endocrinologists, internists, general practitioners and all specialists dealing with diabetes mellitus and connective tissue dysplasia.