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Recently, the atmospheric pressure non-thermal plasma has attracted great attention in biomedical applications due to the advantages of high efficiency, safety, no toxic residue and low cost. In this work, a homemade plasma jet system was constructed. The system which used in this work was a dielectric barrier discharge (DBD) type atmospheric pressure plasma jet (APPJ). It was applied to generate a non-thermal plasma using an alternating current (AC) power supply with two types of noble gases (argon and helium).