And even I can remember A day when historians left blanks in their writings, I mean for things they didn't know. -Ezra Pound, Canto XIII _ The prefaces to the previous volumes of this series have all expressed in various ways the actual motivation behind these collective efforts. There was agreement in most instances that we are facing some kind of publication explosion, and that the present type of compact and personalized reviews may be of help, from both a conceptual and a purely informational standpoint. The aims of the series were, and still are, to focus attention on the rapidly changing…mehr
And even I can remember A day when historians left blanks in their writings, I mean for things they didn't know. -Ezra Pound, Canto XIII _ The prefaces to the previous volumes of this series have all expressed in various ways the actual motivation behind these collective efforts. There was agreement in most instances that we are facing some kind of publication explosion, and that the present type of compact and personalized reviews may be of help, from both a conceptual and a purely informational standpoint. The aims of the series were, and still are, to focus attention on the rapidly changing fields within the realm of immunology, and to present in each chapter the summation of results generated by an investigator or group of Investigators, either as an analysis of their own work or as a correlation of such work with the general field in question. The present volume does not differ in its construction from its predecessors, although it does concentrate on a single target, the T lymphocyte and its biology. The selection of subjects as well as contributors has been the sole responsi bility of this editor; however, the actual format and length of the individual contributions was left to the discretion and inspiration of the different authors. Even the styles, ranging from the concise statement to the meticulously detailed review, attest to the freedom of format.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Two Main Features of T-Cell Development: Thymus Traffic and Postthymic Maturation.- I. Introduction.- II. Postthymic Precursor Cells.- III. Traffic.- IV. Epilogue.- V. References.- 2 Regulation of the Immune Response by T-Cell Subclasses.- I. Introduction.- II. Properties of Three Major T-Cell Subclasses.- III. Possible Mechanisms of TC/S Suppression.- IV. Definition of Other (Non-T) Lymphocyte Subclasses Expressing Distinctive Cell-Surface Components.- V. References.- 3 Antigen Receptors of T Helper Cells.- I. Introduction.- II. Functional Specificity and Heterogeneity of Helper-T-Cell Receptors.- III. Idiotypic Properties of Helper and Suppressor T-Cell Receptors.- IV. Ir Gene Control of Specific Helper Function.- V. Properties of Isolated Antigen-Binding Receptors of Putative T-Cell Origin.- VI. Discussion.- VII. References.- 4 Antigen-Binding, Idiotypic T-Lymphocyte Receptors.- I. Introduction.- II. Methods and Materials Used in the Induction and Analysis of Antiidiotypic Antibodies.- III. Induction and Characteristics of Antiidiotypic Antibodies Raised Against T- or B-Cell Receptors for Antigen.- IV. Inhibition of T-Cell Functions by Antiidiotypic Antibodies.- V. Direct Visualization of Idiotype-Positive T Lymphocytes Using Fluorescent Antibody Techniques, Autoradiography, or Electronmicroscopy Measurements.- VI. Specific Accumulation and Purification of Idiotype-Positive T Lymphocytes.- VII. Demonstration and Characteristics of Naturally Occurring, Idiotypic, Antigen-Binding Molecules Derived from T and B Lymphocytes and Present in Normal Serum.- VIII. Specific Transplantation Tolerance Resulting from Autoimmunity Against Naturally Occurring Idiotype-Positive Receptor Molecules..- IX. General Discussion.- X. References.- 5 Major Transplantation Antigens, Viruses, and Specificity of Surveillance T Cells.- I. Introduction.- II. Virus-Specific Cytotoxic T Cells in Vitro.- III. Restriction of Virus-Specific Effector-T-Cell Functions in Vivo by H-2K or H-2D.- IV. Analysis of the H-2 Compatibility Requirement for Cytolytic T-Cell Interactions.- V. Major Transplantation Antigens and Immunosurveillance.- VI. Conclusions.- VII. References.- 6 Significance of the Major Histocompatibility Complex As Assessed by T-Cell-Mediated Lympholysis Involving Syngeneic Stimulating Cells.- I. The Murine Major Histocompatibility Complex.- II. Requirement of Serologically Detectable Region Homology for Cytotoxicity in Chemically Modified Autologous Systems.- III. Role of H-2-Linked Immune Response Genes.- IV. Conclusions and Speculation.- V. References.- 7 T-Cell-Mediated Cytolysis: An Overview of Some Current Issues.- I. Introduction.- II. Stages in the Lytic Cycle.- III. Overview and Some Possible Future Directions.- IV. References.- 8 Mechanism of T-Cell-Mediated Cytolysis: The Lethal Hit Stage.- I. Introduction.- II. The Three Stages of T-Cell-Mediated Cytolysis.- III. Recognition.- IV. Lethal Hit.- V. Target-Cell Disintegration.- VI. Summary and Conclusions.- VII. References.- 9 Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction.- I. Introduction.- II. Technical Considerations in the Assay of T-Lymphocyte-Mediate d Specific Lysis (TSL).- III. Resolution of TSL into Steps.- IV. Characteristics of Adhesion.- V. Characteristics of Programming for Lysis.- VI. Characteristics of Killer-Cell-Independent Lysis (KCIL).- VII. Sites of Action of Drugs Inhibiting TSL.- VIII. Concluding Remarks.- IX. References.- 10 Functional Analysis of Distinct Human T-Cell Subsets Bearing Unique Differentiation Antigens.- I. Introduction.- II. Surface Properties of Human Lymphocyte Subsets.- III. Methods for the Isolation of Human T Cells and Their Subsets.- IV. Functional Properties of Isolated Human Lymphocyte Subsets.- V. Conclusions.- VI. References.
1 Two Main Features of T-Cell Development: Thymus Traffic and Postthymic Maturation.- I. Introduction.- II. Postthymic Precursor Cells.- III. Traffic.- IV. Epilogue.- V. References.- 2 Regulation of the Immune Response by T-Cell Subclasses.- I. Introduction.- II. Properties of Three Major T-Cell Subclasses.- III. Possible Mechanisms of TC/S Suppression.- IV. Definition of Other (Non-T) Lymphocyte Subclasses Expressing Distinctive Cell-Surface Components.- V. References.- 3 Antigen Receptors of T Helper Cells.- I. Introduction.- II. Functional Specificity and Heterogeneity of Helper-T-Cell Receptors.- III. Idiotypic Properties of Helper and Suppressor T-Cell Receptors.- IV. Ir Gene Control of Specific Helper Function.- V. Properties of Isolated Antigen-Binding Receptors of Putative T-Cell Origin.- VI. Discussion.- VII. References.- 4 Antigen-Binding, Idiotypic T-Lymphocyte Receptors.- I. Introduction.- II. Methods and Materials Used in the Induction and Analysis of Antiidiotypic Antibodies.- III. Induction and Characteristics of Antiidiotypic Antibodies Raised Against T- or B-Cell Receptors for Antigen.- IV. Inhibition of T-Cell Functions by Antiidiotypic Antibodies.- V. Direct Visualization of Idiotype-Positive T Lymphocytes Using Fluorescent Antibody Techniques, Autoradiography, or Electronmicroscopy Measurements.- VI. Specific Accumulation and Purification of Idiotype-Positive T Lymphocytes.- VII. Demonstration and Characteristics of Naturally Occurring, Idiotypic, Antigen-Binding Molecules Derived from T and B Lymphocytes and Present in Normal Serum.- VIII. Specific Transplantation Tolerance Resulting from Autoimmunity Against Naturally Occurring Idiotype-Positive Receptor Molecules..- IX. General Discussion.- X. References.- 5 Major Transplantation Antigens, Viruses, and Specificity of Surveillance T Cells.- I. Introduction.- II. Virus-Specific Cytotoxic T Cells in Vitro.- III. Restriction of Virus-Specific Effector-T-Cell Functions in Vivo by H-2K or H-2D.- IV. Analysis of the H-2 Compatibility Requirement for Cytolytic T-Cell Interactions.- V. Major Transplantation Antigens and Immunosurveillance.- VI. Conclusions.- VII. References.- 6 Significance of the Major Histocompatibility Complex As Assessed by T-Cell-Mediated Lympholysis Involving Syngeneic Stimulating Cells.- I. The Murine Major Histocompatibility Complex.- II. Requirement of Serologically Detectable Region Homology for Cytotoxicity in Chemically Modified Autologous Systems.- III. Role of H-2-Linked Immune Response Genes.- IV. Conclusions and Speculation.- V. References.- 7 T-Cell-Mediated Cytolysis: An Overview of Some Current Issues.- I. Introduction.- II. Stages in the Lytic Cycle.- III. Overview and Some Possible Future Directions.- IV. References.- 8 Mechanism of T-Cell-Mediated Cytolysis: The Lethal Hit Stage.- I. Introduction.- II. The Three Stages of T-Cell-Mediated Cytolysis.- III. Recognition.- IV. Lethal Hit.- V. Target-Cell Disintegration.- VI. Summary and Conclusions.- VII. References.- 9 Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction.- I. Introduction.- II. Technical Considerations in the Assay of T-Lymphocyte-Mediate d Specific Lysis (TSL).- III. Resolution of TSL into Steps.- IV. Characteristics of Adhesion.- V. Characteristics of Programming for Lysis.- VI. Characteristics of Killer-Cell-Independent Lysis (KCIL).- VII. Sites of Action of Drugs Inhibiting TSL.- VIII. Concluding Remarks.- IX. References.- 10 Functional Analysis of Distinct Human T-Cell Subsets Bearing Unique Differentiation Antigens.- I. Introduction.- II. Surface Properties of Human Lymphocyte Subsets.- III. Methods for the Isolation of Human T Cells and Their Subsets.- IV. Functional Properties of Isolated Human Lymphocyte Subsets.- V. Conclusions.- VI. References.
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