Although the field of contemporary immunobiology continues to diversify and encompass an increasing array of biomedical disciplines and topics, there are frequently several themes that will receive special emphasis and prominence at any given time. It is our hope that this series will reflect these themes and pro vide an appropriate venue for exposure of such topics at a useful time. Although this particular volume is not designated as one of the special topics volumes in this series, the selected topics have in essence come together to con sider aspects of two major areas of considerable…mehr
Although the field of contemporary immunobiology continues to diversify and encompass an increasing array of biomedical disciplines and topics, there are frequently several themes that will receive special emphasis and prominence at any given time. It is our hope that this series will reflect these themes and pro vide an appropriate venue for exposure of such topics at a useful time. Although this particular volume is not designated as one of the special topics volumes in this series, the selected topics have in essence come together to con sider aspects of two major areas of considerable research interest in immuno biology today. These concern new approaches and insights into an understanding of the tumor-host relationship, and aspects of cellular interactions and networks as approached by various different lines of investigation. The province of tumor immunology remains one of the most challenging areas to immunologists, as it of necessity involves not only developing an under standing of the neoplastic process itself and how the immune system responds, but of eventually using this information in a diagnostic or therapeutic manner.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Cancer: A Problem in Somatic Cell Evolution.- I. Introduction.- II. Is Escape from Senescence on the Pathway to Cancer?.- III. Are Metastases or Angiogenesis on the Pathway to Cancer?.- IV. Is Anchorage-Independent Growth on the Pathway to Cancer?.- V. Can We Put Order in the Data Concerning the Immune Response to Tumors?.- VI. Natural Killer Activity and Cancer.- VII. The Bottom Line.- VIII. References.- 2 The Genetic and Cellular Basis of Regulation of the Immune Response to Tumor Antigens.- I. Introduction.- II. Cellular Interactions.- III. Genetic Basis of the Immune Response to Tumor Antigens.- IV. Effector T Cells.- V. Suppressor T Cells.- VI. Summary.- VII. References.- 3 Monoclonal Antibodies to Tumor Antigens.- I. Introduction.- II. Methodology.- III. Antigens of Mouse Tumors.- IV. Antigens of Human Tumors.- V. Conclusions.- VI. References.- 4 Continuous Cytotoxic T-Cell Lines.- I. Introduction.- II. Cytolytic T-Lymphocyte Lines.- III. Methods for Culturing T Cells.- IV. The Immunobiologic Significance of TCGF(IL2).- V. Conclusions.- VI. References.- 5 The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation.- I. Introduction.- II. Each T Lymphoma Will Bear Surface Receptors Which Specifically Recognize Its Inducing MuLV.- III. Retrovirus Receptors Can Be Used to Distinguish Incipient T Lymphomas from Other T Cells.- IV. Substances Which Interfere with Receptor Binding Inhibit T-Lymphoma Proliferation.- V. T-Lymphoma Receptors Should Have Variable Regions Analogous to Immunoglobulins and Normal T-Cell Receptors.- VI. Continuous in Vivo Antigenic Stimulation of Appropriate Normal T-Cell Clones Should Also Be Lymphomagenic.- VII. Concluding Remarks.- VIII. References.- 6 On Network Theory and H-2 Restriction.- I. Introduction.- II. The Cross-Linking Postulate and Symmetry in the System.- III. The Antigen-Specific T-Cell-Factor Postulate.- IV. The Nonspecific T-Cell-Dependent Helper Factor Postulate.- V. Summary of the Postulates of the Model.- VI. The Stable States.- VII. Modes of Response of the System.- VIII. Is the Model Too Simple? Subclasses of T Cells.- IX. The T-Cell Repertoire.- X. Implications of the Theory for the Design of Experiments.- XI. Recapitulation.- XII. On the Analogy with the Central Nervous System.- XIII. References.- 7 VH Gene Products Allow Specific Communication among Immunologic Cell Sets.- I. Introduction.- II. Genetic and Serologic Definition of Idiotype on B and T Cells.- III. Influence of Anti-Idiotypic Antibodies on Idiotype Expression.- IV. id-Specific Suppression by T Cells.- A. Cellular Targets of id-Specific T Suppression.- V. Idiotype-Specific Activation by T Cells.- VI. References.- 8 Radiation-Induced Augmentation of the Immune Response.- I. Introduction.- II. Review of Published Data.- III. Interpretation.- IV. Work in Progress and Future Initiatives.- V. Summary.- VI. References.- 9 Antibody Production to Antigen-Specific Factors.- I. Introduction.- II. Methods.- III. Rabbit Antisera to Suppressor Factor.- IV. Mouse Antisera to Suppressor Factor.- V. Antisera to Helper Factors.- VI. A Model of Specific Factor Structure.- VII. Conclusions and Prospects.- VIII. References.
1 Cancer: A Problem in Somatic Cell Evolution.- I. Introduction.- II. Is Escape from Senescence on the Pathway to Cancer?.- III. Are Metastases or Angiogenesis on the Pathway to Cancer?.- IV. Is Anchorage-Independent Growth on the Pathway to Cancer?.- V. Can We Put Order in the Data Concerning the Immune Response to Tumors?.- VI. Natural Killer Activity and Cancer.- VII. The Bottom Line.- VIII. References.- 2 The Genetic and Cellular Basis of Regulation of the Immune Response to Tumor Antigens.- I. Introduction.- II. Cellular Interactions.- III. Genetic Basis of the Immune Response to Tumor Antigens.- IV. Effector T Cells.- V. Suppressor T Cells.- VI. Summary.- VII. References.- 3 Monoclonal Antibodies to Tumor Antigens.- I. Introduction.- II. Methodology.- III. Antigens of Mouse Tumors.- IV. Antigens of Human Tumors.- V. Conclusions.- VI. References.- 4 Continuous Cytotoxic T-Cell Lines.- I. Introduction.- II. Cytolytic T-Lymphocyte Lines.- III. Methods for Culturing T Cells.- IV. The Immunobiologic Significance of TCGF(IL2).- V. Conclusions.- VI. References.- 5 The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation.- I. Introduction.- II. Each T Lymphoma Will Bear Surface Receptors Which Specifically Recognize Its Inducing MuLV.- III. Retrovirus Receptors Can Be Used to Distinguish Incipient T Lymphomas from Other T Cells.- IV. Substances Which Interfere with Receptor Binding Inhibit T-Lymphoma Proliferation.- V. T-Lymphoma Receptors Should Have Variable Regions Analogous to Immunoglobulins and Normal T-Cell Receptors.- VI. Continuous in Vivo Antigenic Stimulation of Appropriate Normal T-Cell Clones Should Also Be Lymphomagenic.- VII. Concluding Remarks.- VIII. References.- 6 On Network Theory and H-2 Restriction.- I. Introduction.- II. The Cross-Linking Postulate and Symmetry in the System.- III. The Antigen-Specific T-Cell-Factor Postulate.- IV. The Nonspecific T-Cell-Dependent Helper Factor Postulate.- V. Summary of the Postulates of the Model.- VI. The Stable States.- VII. Modes of Response of the System.- VIII. Is the Model Too Simple? Subclasses of T Cells.- IX. The T-Cell Repertoire.- X. Implications of the Theory for the Design of Experiments.- XI. Recapitulation.- XII. On the Analogy with the Central Nervous System.- XIII. References.- 7 VH Gene Products Allow Specific Communication among Immunologic Cell Sets.- I. Introduction.- II. Genetic and Serologic Definition of Idiotype on B and T Cells.- III. Influence of Anti-Idiotypic Antibodies on Idiotype Expression.- IV. id-Specific Suppression by T Cells.- A. Cellular Targets of id-Specific T Suppression.- V. Idiotype-Specific Activation by T Cells.- VI. References.- 8 Radiation-Induced Augmentation of the Immune Response.- I. Introduction.- II. Review of Published Data.- III. Interpretation.- IV. Work in Progress and Future Initiatives.- V. Summary.- VI. References.- 9 Antibody Production to Antigen-Specific Factors.- I. Introduction.- II. Methods.- III. Rabbit Antisera to Suppressor Factor.- IV. Mouse Antisera to Suppressor Factor.- V. Antisera to Helper Factors.- VI. A Model of Specific Factor Structure.- VII. Conclusions and Prospects.- VIII. References.
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