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Chronic kidney disease affects about 10 % of the world population. In most developing nations, the costs for the treatment of CKD are met by patients. Data on the economic burden of early stages of CKD are scarce; few studies have evaluated the cost of management of CKD stages 3-5 non-dialyzed in an out-of-pocket expenditure system. This study estimated the direct, indirect and the global economic cost of management of CKD stages 3-5 ND patients in Yaoundé. It was a month retrospective cost analysis. Sampling was consecutive and exhaustive of CKD 3-5 ND patients. We evaluated direct medical, direct non-medical and indirect costs. 69 patients were included in the study and the mean age was 55 years. The median monthly salary of the population was $ 162. Only 1.4% of patients had 100% coverage. The total cost of management was about $ 163. Direct medical, direct non-medical and indirect costs accounted for 86.4 %, 7.1 % and 6.3 % respectively. That global cost was prohibitive to Cameroonians and was tantamount to 2.7 times the minimal wage in Cameroon. There is an urgent need for establishing a national health insurance Scheme in these countries.