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Related covid-19 and new Variant and treatment like vaccine it is relevant to deeply verify the immunologic implication and in a special way regarding the innate immune sensor system and the evasion of the immune system.This can be crucial to search for new strategies to fight this severe disease under an Toxicology-antidotes point of view.The rapid emergence of a new variant is under study by researchers because some of these show different responses to antibodies as reported in literature. ( vaccine efficacy ?)In this article after a review part it is submitted a collection of hypothesis of solution to contrast covid-19 Spread and mortality and project hypothesis.