The emergence of Coronavirus has thrown the world in the midst of a new pandemic. Equitable access to safe and effective vaccines is critical to ending the COVID-19 pandemic. Every level of medical sciences referred to vaccination is the key way to human safety against the COVID -19 viruses. As a third-world country, India has faced many challenges to vaccination among the largest population. The present volume COVID Vaccine: Issues and challenges emphases on COVID-19 Vaccination Issues and Challenges in India, Indian Foreign Policy and COVID Vaccine, A critical analysis of covid-19 vaccine hesitancy among adolescents, Natural immunity versus vaccination immunity, School students academic stress and anxiety in the covid-19 vaccination, etc.