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The present text book of "COX-2 inhibitors" is very informative for M. Pharm, Ph. D and academic/industrial researched who are exhaustively engage with drug discovery on selective COX-2 inhibitor. This book includes enzyme structure, pharmacological action, Current marketed drugs, Withdrawal of COX-2 drug, newer COX-2 inhibitors and Drug interaction of COX-2 innibitors. We have tried graphical representation of various contents in this book for description of in simplified language and for better clarity of content.