Aida Charfi

Crossing over in the HLA region

• Broschiertes Buch

Produktbeschreibung

Bone marrow transplants are the treatment of choice for many malignant and non-malignant diseases, such as leukemia, bone marrow aplasia and immune deficiency. In Tunisia, only allogeneic or allograft transplants are performed between a recipient and an HLA-identical donor. Such geno-identical donors are found in the siblings of patients who are candidates for BM transplants. Donors are first selected on the basis of histocompatibility class I (HLA-A and B) by serology. This is followed by PCR-SSP or PCR-SSO for HLA class II typing of the recipient and any compatible donor. Given that all the HLA typing kits we use are of low resolution, a microsatellite screening approach has been developed. HLA typing is completed by genotyping a panel of 4 microsatellites covering the entire HLA region. The study of haplotype segregation using this panel in the various family members of a candidate for OM transplantation enabled us to highlight genetic or CO recombinations in the HLA region.

Produktdetails

• Verlag: Our Knowledge Publishing
• Seitenzahl: 52
• Erscheinungstermin: 3. Oktober 2023
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 96g
• ISBN-13: 9786206517955
• ISBN-10: 6206517950
• Artikelnr.: 69089663

Autorenporträt

Diploma di maturità 2003Laurea in medicina nel 2016superamento del concorso per assistenti nel 2016Attualmente assistente presso l'ospedale universitario nel laboratorio di immunologia e istocompatibilità dell'ospedale universitario Hédi Chaker, Sfax, Tunisia.