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Cancer is one of the disease with up raised constant mutations and difficult to cure due to metastatic tumors and cell-cell communications between the tumors and the cell through stromal microenvironment and cell signaling. Integrin alpha11beta1 acts as a stromal receptor and remodifies collagen through communication between the storma and collagen related genes contributing majorly to metastasis in NSCLC. other proteins like TWIST, BRCA-1,BRCA-2,Cell adhesion proteins, MMPs, Tetraspanin can contribute to metastasis in cancer through promoting key events like cell migration, Extravasation,Hyperplasiaor Angiogenesis.