Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
From Biology to Drug Discovery
Herausgegeben von Brandon, Nicholas J.; West, Anthony R.
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
From Biology to Drug Discovery
Herausgegeben von Brandon, Nicholas J.; West, Anthony R.
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This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.…mehr
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- Produktdetails
- Wiley series in drug discovery and development
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 400
- Erscheinungstermin: August 2014
- Englisch
- Abmessung: 236mm x 157mm x 28mm
- Gewicht: 703g
- ISBN-13: 9780470566688
- ISBN-10: 047056668X
- Artikelnr.: 35482996
- Wiley series in drug discovery and development
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 400
- Erscheinungstermin: August 2014
- Englisch
- Abmessung: 236mm x 157mm x 28mm
- Gewicht: 703g
- ISBN-13: 9780470566688
- ISBN-10: 047056668X
- Artikelnr.: 35482996
SIGNALING IN THE CNS 1 Marco Conti and Wito Richter 2 PUTTING TOGETHER THE
PIECES OF PHOSPHODIESTERASE DISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW
PUZZLE OF CYCLIC NUCLEOTIDE REGULATION 47 Michy P. Kelly 3
COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDE SIGNALING IN THE
CNS 59 Manuela Zaccolo and Alessandra Stangherlin 4 PHARMACOLOGICAL
MANIPULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE SIGNALING FOR THE
TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS IN THE BRAIN 77 Frank
S. Menniti, Niels Plath, Niels Svenstrup, and Christopher J. Schmidt 5
RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENT AND CNS
APPLICATIONS 115 David P. Rotella 6 CRYSTAL STRUCTURES OF
PHOSPHODIESTERASES AND IMPLICATION ON DISCOVERY OF INHIBITORS 145 Hengming
Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang 7 INHIBITION OF CYCLIC
NUCLEOTIDE PHOSPHODIESTERASES TO REGULATE MEMORY 171 Han-Ting Zhang, Ying
Xu, and James O'Donnell 8 EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC
DISORDERS: TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT
THERAPEUTIC STRATEGIES 211 Sandra P. Zoubovsky, Nicholas J. Brandon, and
Akira Sawa 9 BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY IN
THE CENTRAL NERVOUS SYSTEM 223 Eva P.P. Bollen, Kris Rutten, Olga A.H.
Reneerkens, Harry M.W. Steinbusch, and Jos Prickaerts 10 MOLECULAR AND
CELLULAR UNDERSTANDING OF PDE10A: A DUAL-SUBSTRATE PHOSPHODIESTERASE WITH
THERAPEUTIC POTENTIAL TO MODULATE BASAL GANGLIA FUNCTION 247 Erik I.
Charych and Nicholas J. Brandon 11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND
PHOSPHODIESTERASE ACTIVATION IN THE MODULATION OF ELECTROPHYSIOLOGICAL
ACTIVITY OF CENTRAL NEURONS 269 Sarah Threlfell and Anthony R. West 12 THE
ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMS GOVERNING MOTIVATED BEHAVIOR
303 Gretchen L. Snyder, Joseph P. Hendrick, and Akinori Nishi 13 INHIBITION
OF PHOSPHODIESTERASES AS A STRATEGY FOR TREATMENT OF SPINAL CORD INJURY 353
Elena Nikulina and Marie T. Filbin INDEX 375
SIGNALING IN THE CNS 1 Marco Conti and Wito Richter 2 PUTTING TOGETHER THE
PIECES OF PHOSPHODIESTERASE DISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW
PUZZLE OF CYCLIC NUCLEOTIDE REGULATION 47 Michy P. Kelly 3
COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDE SIGNALING IN THE
CNS 59 Manuela Zaccolo and Alessandra Stangherlin 4 PHARMACOLOGICAL
MANIPULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE SIGNALING FOR THE
TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS IN THE BRAIN 77 Frank
S. Menniti, Niels Plath, Niels Svenstrup, and Christopher J. Schmidt 5
RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENT AND CNS
APPLICATIONS 115 David P. Rotella 6 CRYSTAL STRUCTURES OF
PHOSPHODIESTERASES AND IMPLICATION ON DISCOVERY OF INHIBITORS 145 Hengming
Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang 7 INHIBITION OF CYCLIC
NUCLEOTIDE PHOSPHODIESTERASES TO REGULATE MEMORY 171 Han-Ting Zhang, Ying
Xu, and James O'Donnell 8 EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC
DISORDERS: TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT
THERAPEUTIC STRATEGIES 211 Sandra P. Zoubovsky, Nicholas J. Brandon, and
Akira Sawa 9 BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY IN
THE CENTRAL NERVOUS SYSTEM 223 Eva P.P. Bollen, Kris Rutten, Olga A.H.
Reneerkens, Harry M.W. Steinbusch, and Jos Prickaerts 10 MOLECULAR AND
CELLULAR UNDERSTANDING OF PDE10A: A DUAL-SUBSTRATE PHOSPHODIESTERASE WITH
THERAPEUTIC POTENTIAL TO MODULATE BASAL GANGLIA FUNCTION 247 Erik I.
Charych and Nicholas J. Brandon 11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND
PHOSPHODIESTERASE ACTIVATION IN THE MODULATION OF ELECTROPHYSIOLOGICAL
ACTIVITY OF CENTRAL NEURONS 269 Sarah Threlfell and Anthony R. West 12 THE
ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMS GOVERNING MOTIVATED BEHAVIOR
303 Gretchen L. Snyder, Joseph P. Hendrick, and Akinori Nishi 13 INHIBITION
OF PHOSPHODIESTERASES AS A STRATEGY FOR TREATMENT OF SPINAL CORD INJURY 353
Elena Nikulina and Marie T. Filbin INDEX 375