Cystic Fibrosis (CF) is a genetic disease with a high degree of severity and progression that generates emotional damage in patients and family members. In order to characterize from a psycho-social point of view patients diagnosed with Cystic Fibrosis, a descriptive, cross-sectional, observational study with a quantitative and qualitative approach was conducted. We worked with 14 patients. Instruments were applied to measure anxiety, depression, self-esteem, disease status and search for areas of conflict, interests, motivations, aspirations, needs, family ties, school activity and interpersonal relationships. The patients were mainly of school age, especially adolescents. The qualitative analysis identified that dysfunctional families, with difficulties in coping with the disease, generated higher levels of anxiety in the patient and difficulties with self-esteem, although not with the evolution of the disease.