Cytochrome P450

Structure, Mechanism, and Biochemistry
Herausgegeben:Ortiz de Montellano, Paul R.

• Broschiertes Buch

Produktbeschreibung

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4419-3443-7
• 3rd ed.
• Seitenzahl: 712
• Erscheinungstermin: 29. Oktober 2010
• Englisch
• Abmessung: 254mm x 178mm x 38mm
• Gewicht: 1296g
• ISBN-13: 9781441934437
• ISBN-10: 144193443X
• Artikelnr.: 32109375

Inhaltsangabe

Models and Mechanisms of Cytochrome P450 Action.- Computational Approaches to Cytochrome P450 Function.- Structures of Cytochrome P450 Enzymes.- Electron Transfer Partners of Cytochrome P450.- Activation of Molecular Oxygen by Cytochrome P450.- Substrate Oxidation by Cytochrome P450 Enzymes.- Inhibition of Cytochrome P450 Enzymes.- Induction of Cytochrome P450 Enzymes.- Hormonal Regulation of Liver Cytochrome P450 Enzymes.- Human Cytochrome P450 Enzymes.- Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids.- Cytochrome P450s in Plants.- The Diversity and Importance of Microbial Cytochromes P450.

Rezensionen

Praise for the Second Edition: `Professor Paul R. Ortiz de Montellano (known in some databases as 'P.R.O. Demontellano' has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters.' ISSX: International Society for Study of Xenobiotics (October 1996) `The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus.' Science, 271 (March 1996)