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Our study aaimed to investigate the possible ameliorative effect of some natural products as royal jelly on some patients suffered from organs transplantations and handelling some immunosupresive agents as cyclosporin A on the fertility and chromosomes abnormalities. The results obtained that cyclosporine A induced many sperm abnormalities and some cytogenetical changes of some parameters. Also royal jelly obtained ameliorative changes caused by cyclosporine A