Cytokine gene polymorphisms in visceral leishmaniasis Iraqi patients - Idan, Ekhlas
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Visceral leishmaniasis (VL) is a severe chronic systemic zoonotic disease caused by the protozoan Leishmania donovani or L. infantum, in which cytokines play an important role in its pathogenesis. These cytokines are under genetic control, and their gene polymorphisms have been suggested to exert a functional role in regulating cytokine gene expression. Therefore, the present study determined IFN-Gamma,IL-2, IL-10 and IL-12 serum levels and gene polymorphisms of 11 cytokine and cytokine receptor genes (IL1A, IL1B, IL2, IL4, IL4R, IL6, IL10, IL12B, TNF, IFNG and TGFB1) in VL patients by ELISA…mehr

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Produktbeschreibung
Visceral leishmaniasis (VL) is a severe chronic systemic zoonotic disease caused by the protozoan Leishmania donovani or L. infantum, in which cytokines play an important role in its pathogenesis. These cytokines are under genetic control, and their gene polymorphisms have been suggested to exert a functional role in regulating cytokine gene expression. Therefore, the present study determined IFN-Gamma,IL-2, IL-10 and IL-12 serum levels and gene polymorphisms of 11 cytokine and cytokine receptor genes (IL1A, IL1B, IL2, IL4, IL4R, IL6, IL10, IL12B, TNF, IFNG and TGFB1) in VL patients by ELISA assay and sequence specific primer-PCR method. Gene polymorphism impact on IFN-Gamma, IL-2, IL-10 and IL-12 serum levels was also evaluated. These evaluations were carried out on Iraqi Arab children with VL.
Autorenporträt
Dr. Zahra'a A. Ahmad is a lecturer at the Department of Biology, College of Science for Women, University of Baghdad; from which she obtained her PhD in 2015. Her keen interest is teaching and carrying out research related to topics in parasitology, immunology and immunogenetics.