Gressner

Cytokines in Liver Injury and Repair

Herausgegeben:Gressner, A. M.; Heinrich, P. C.; Matern, S.

• Gebundenes Buch

Produktbeschreibung

This book, the proceedings of Falk Symposium No. 125 on 'Cytokines in Liver Injury and Repair' (Progress in Gastroenterology and Hepatology Part II), held in Hannover, Germany, on September 30 - October 1, 2001, provides an update of our current knowledge on the role of cytokines in various human and experimental liver diseases and on their present and prospective use in therapeutic trials.

The book contains chapters by most well-known experts in the field who have contributed significantly to our present knowledge on cytokines in liver injury and repair.

Produktdetails

• Falk Symposium 125
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 978-0-7923-8775-6
• 2002
• Seitenzahl: 400
• Erscheinungstermin: 30. Juni 2002
• Englisch
• Abmessung: 241mm x 160mm x 29mm
• Gewicht: 833g
• ISBN-13: 9780792387756
• ISBN-10: 0792387759
• Artikelnr.: 22112485

Inhaltsangabe

Preface. Section I: Cytokine-Induced Cell Death. 1. Endogenous modulators
of receptor-mediated hepatic cell death; H. Hentze, et al. 2. Modulation of
CD 95 (APO-1/Fas) induced hepatocyte death by NO; PR. Galle, et al. 3.
TGF-beta-induced liver cell apoptosis; R. Schulte-Hermann, et al. Section
II: Regulation of Normal and Malignant Cell Growth by Cytokines. 4.
Proliferative and apoptotic effects of tumour necrosis factor in the liver
and cells in culture; N. Fausto, J. Campbell. 5. The role of insulin-like
growth factor-II in hepatocarcinogenesis; P. Lund, et al. 6. Transforming
growth factor-beta and cancer; M. Reiss. 7. Cytokines and hepatitis C virus
replication; D. Moradpour, et al. Section III: Cytokine Signals in
Fibrogenesis. 8. Role of DDR2 receptor in the activation of hepatic
stellate cells; E. Olaso, et al. 9. PDGF signalling in activated stellate
cells; M. Pinzani. 10. Escape of activated hepatic stellate cells from
TGF-beta control; S. Dooley, et al. 11. Chemokines in the modulation of
liver inflammation; F. Marra, et al. Section IV: Modulation of Fibrogenic
Cytokine Response. 12. Identification of fibrogenic genes in a polygenic
mouse model of liver fibrosis; F. Lammert, et al. 13. Cytokine transgenic
models of fibrogenesis; S. Kanzler. 14. The fibrogenic mediators of
TGF-beta and TNF-alpha as surviving factors for activated hepatic stellate
cells; G. Ramadori, B. Saile. 15. Resolution of fibrosis by apoptosis of
myofibroblasts; F. Murphy, J.P. Iredale. Section V: Cytokines in the Cause
and Consequence of Cholestatis. 16. Regulation of hepatic organic anion
transporters by cytokines; A. Geier, et al. 17. Reaction of cholangiocytes
to inflammatory injury; C. Spirlì, et al. 18. Bid antisense
oligodeoxynucleotides as therapy for cholestatic liver injury; H. Higuchi,
G.J. Gores. Section VI: Polymorphisms of Cytokines and Signalling. 19.
Regulation of interleukin-6-type cytokine signaling; P.C. Heinrich, et al.
20. IL6-dependent signal transduction and its relevance in animal models;
K.L. Streetz, et al. 21. Predictive value of cytokine polymorphisms for
liver disease; P.T. Donaldson, C.P. Day. Section VII: Therapeutic Cytokines
and Modulators. 22. PPARγ and fibrogenesis; T. Miyahara, et al. 23.
Cytokine modulation in the therapy of hepatic immunopathology and fibrosis;
S.M. Wahl, et al. 24. Matrix binding motifs and peptide mimetics as
modulators of wound healing and fibrogenesis; D. Schuppan, et al. 25.
Endothelin and liver injury &endash; therapeutic antagonism of the
endothelin system; D.C. Rockey. 26. Transforming growth factor β in the
treatment of autoimmune disease; A.W. Lohse. Section VIII:
Cytokine-Assisted Gene Therapies. 27. The feasibility of antifibrotic gene
therapy; T.J. Davern, D.M. Bissell. 28. Experimental approaches to
antifibrotic strategies using gene transfer; R. Weiskirchen, et al. 29.
Cytokine-assisted gene therapy: Anti-TGF-β intervention using mutated forms
of TGF-β receptor; H. Ueno, et al. 30. Cytokine-based gene therapy of
hepatocellular carcinoma (HCC); C. Qian, et al. Index.