Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the…mehr
Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Jason Kelley is Professor of Medicine at the University of Vermont College of Medicine, Burlington, and Director of the Medical Intensive Care Unit, Medical Center Hospital of \fermont, Burlington. He is the author or coauthor of more than 60 professional papers, reports, and abstracts that reflect his research interests in cytokines and pulmonary disease. Dr. Kelley is a member of the American Society for Cell Biology, the Biochemical Society, the American Thoracic Society, and the American Association for the Advancement of Science, among other organizations. He received the A.B. degree (1966) in physics from Harvard University, Cambridge, Massachusetts, and the M.D. degree (1972) from the University of Texas Southwestern Medical School at Dallas.
Inhaltsangabe
Introduction Preface Contributors Part I MITOGENIC CYTOKINES 1. Platelet Derived Growth Factor /James P. Fabisiak and Jason Kelley I. Introduction II. Protein Structure III. Gene Structure, Organization, and Processing IV. PDGF Receptors V. Biological Properties of PDGFs VI. Cellular Sources of PDGF VII. Regulation of PDGF VIII. PDGF in Lung Disease IX. Conclusions References 2. Fibroblast Growth Factors /David Moscatelli I. Introduction IL History of FGFs III. Structural Properties IV. FGF Receptors V. Interaction with Extracellular Matrix VI. Biological Properties VIL The Role of FGFs in Tumor Formation VIII. FGFs in Lung Biology References 3. Insulin Like Growth Factors /Alan D. Stiles, Billie M. Moats Staats, and George Z. Retsch Bogart I. Introduction II. IGF Peptides III. IGF Genes and Transcripts IV. IGF Receptors V. IGF Binding Proteins VI. Actions of IGFs VIL Role of IGFs in Fetal Growth VIII. Role of IGFs in Postnatal Growth IX. IGFs and Lung X. Summary References 4. Transforming Growth Factor ,8 /Jason Kelley I. Introduction II. The TGF ß Family of Proteins III. Biosynthesis of TGF ß IV. Gene Structure of TGF ,Bs V. Control of TGF ß Gene Expression VI. Autoinduction of TGF ß Gene Expression VII. Activation of TGF ß Protein VIII. Receptors for TGF ß IX. Signaling Pathways for TGF ß X. TGF ß as a Mitogen XL Antiproliferative Effects of TGF ß XII. TGF ß and Extracellular Matrix XIII. Interactions Between TGF ß and Other Cytokines XIV. TGF ß and the Immune System xv. TGF ß in Monocyte Macrophages, Granulocytes, and Mast Cells XVI. TGF ß in Fibroblasts XVII. Assays for TGF ß XVIII. TGF ß in Lung XIX. TGF ß in Remodeling and Fibrosis xx. Future Directions References 5. Transforming Growth Factor a and Epidermal Growth Factor /David K. Madtes I. Introduction II. The Growth Factor Pr
Introduction Preface Contributors Part I MITOGENIC CYTOKINES 1. Platelet Derived Growth Factor /James P. Fabisiak and Jason Kelley I. Introduction II. Protein Structure III. Gene Structure, Organization, and Processing IV. PDGF Receptors V. Biological Properties of PDGFs VI. Cellular Sources of PDGF VII. Regulation of PDGF VIII. PDGF in Lung Disease IX. Conclusions References 2. Fibroblast Growth Factors /David Moscatelli I. Introduction IL History of FGFs III. Structural Properties IV. FGF Receptors V. Interaction with Extracellular Matrix VI. Biological Properties VIL The Role of FGFs in Tumor Formation VIII. FGFs in Lung Biology References 3. Insulin Like Growth Factors /Alan D. Stiles, Billie M. Moats Staats, and George Z. Retsch Bogart I. Introduction II. IGF Peptides III. IGF Genes and Transcripts IV. IGF Receptors V. IGF Binding Proteins VI. Actions of IGFs VIL Role of IGFs in Fetal Growth VIII. Role of IGFs in Postnatal Growth IX. IGFs and Lung X. Summary References 4. Transforming Growth Factor ,8 /Jason Kelley I. Introduction II. The TGF ß Family of Proteins III. Biosynthesis of TGF ß IV. Gene Structure of TGF ,Bs V. Control of TGF ß Gene Expression VI. Autoinduction of TGF ß Gene Expression VII. Activation of TGF ß Protein VIII. Receptors for TGF ß IX. Signaling Pathways for TGF ß X. TGF ß as a Mitogen XL Antiproliferative Effects of TGF ß XII. TGF ß and Extracellular Matrix XIII. Interactions Between TGF ß and Other Cytokines XIV. TGF ß and the Immune System xv. TGF ß in Monocyte Macrophages, Granulocytes, and Mast Cells XVI. TGF ß in Fibroblasts XVII. Assays for TGF ß XVIII. TGF ß in Lung XIX. TGF ß in Remodeling and Fibrosis xx. Future Directions References 5. Transforming Growth Factor a and Epidermal Growth Factor /David K. Madtes I. Introduction II. The Growth Factor Pr
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