Dendritic Cell-based Vaccine Strategies in MTB Infection - Dube, Nothabo;Garira, Winston;Magombedze, Gesham
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Dendritic cells (DCs) are known to play a pivotal role in linking the innate and adaptiveimmune mechanisms. We study the effects of a Dendritic cell based vaccine in the fightagainst Mycobacterium tuberculosis. First a model without immune response is considered, then a model with T and CTL mechanisms, then a model with T,CTL and Dendritic cells and finally a model with a dendritic cell-based vaccine. From our model analysis, we conclude that the introduction of a cell-based vaccine can go a long way towards the effective control of the Mtb infection.

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Produktbeschreibung
Dendritic cells (DCs) are known to play a pivotal role in linking the innate and adaptiveimmune mechanisms. We study the effects of a Dendritic cell based vaccine in the fightagainst Mycobacterium tuberculosis. First a model without immune response is considered, then a model with T and CTL mechanisms, then a model with T,CTL and Dendritic cells and finally a model with a dendritic cell-based vaccine. From our model analysis, we conclude that the introduction of a cell-based vaccine can go a long way towards the effective control of the Mtb infection.
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Autorenporträt
Holder of an MSc Degree in Industrial Mathematics and an Honors Degree in Applied Mathematics. Main research interest in Mathematical Biology.