Dendritic Cell-based Vaccine Strategies in MTB Infection - Dube, Nothabo;Garira, Winston;Magombedze, Gesham
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Dendritic cells (DCs) are known to play a pivotal role in linking the innate and adaptiveimmune mechanisms. We study the effects of a Dendritic cell based vaccine in the fightagainst Mycobacterium tuberculosis. First a model without immune response is considered, then a model with T and CTL mechanisms, then a model with T,CTL and Dendritic cells and finally a model with a dendritic cell-based vaccine. From our model analysis, we conclude that the introduction of a cell-based vaccine can go a long way towards the effective control of the Mtb infection.

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Produktbeschreibung
Dendritic cells (DCs) are known to play a pivotal role in linking the innate and adaptiveimmune mechanisms. We study the effects of a Dendritic cell based vaccine in the fightagainst Mycobacterium tuberculosis. First a model without immune response is considered, then a model with T and CTL mechanisms, then a model with T,CTL and Dendritic cells and finally a model with a dendritic cell-based vaccine. From our model analysis, we conclude that the introduction of a cell-based vaccine can go a long way towards the effective control of the Mtb infection.
Autorenporträt
Holder of an MSc Degree in Industrial Mathematics and an Honors Degree in Applied Mathematics. Main research interest in Mathematical Biology.