Dendritic cells for the treatment of autoimmune disease - Lim, Dae-Seog;Lee, Jun-Ho;Byun, Sei-Hee
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A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. The results presented herein show that type II collagen-pulsed Rosi-DCs ameliorate the inflammation associated with CIA via the induction of Treg cell population. These results suggest that rosiglitazone-mediated DCs hold promise as a novel therapeutic strategy for RA.

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Produktbeschreibung
A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. The results presented herein show that type II collagen-pulsed Rosi-DCs ameliorate the inflammation associated with CIA via the induction of Treg cell population. These results suggest that rosiglitazone-mediated DCs hold promise as a novel therapeutic strategy for RA.
Autorenporträt
Education and Positions1992: B.C., Konkuk University, Republic of Korea1994: M.S., Konkuk University Graduate School, Republic of Korea2003: Ph.D., Konkuk University Graduate School, Republic of Korea2009~Present: Associate Professor, Dept. of Biotechnology, CHA Univ.Detailed MajorEverything related to dendritic cells