Dentine hypersensitivity is a condition often termed as "enigma being frequently encountered but poorly understood". A complete knowledge and understanding of the mechanisms underlying dentine sensitivity will go a long way in managing it. Although, a wide variety of factors contribute to the exposure of dentinal tubules, current desensitizing treatment tends to concentrate on two approaches; to occlude the tubules and to block the neurotransmission.In office desensitizing agents applied topically deliver a wide range of more complex and more potent desensitizing treatment. Therefore this book would be of immense value for Academicians and Clinicians to effectively manage Dentine hypersensitivity.