Design & Developement of Floating Tablet of Tolperisone Hydrochloride - Soni, Ravi;Patel, Mukesh;Patel, Natvarlal
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Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone].…mehr

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Produktbeschreibung
Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.
Autorenporträt
Ravikumar P. SoniShri B.M. Shah College of Pharmaceutical Education and Research. Education:I received my B. Pharm from Vidya bharti trust college of pharmacy in 2010 (with English), my M. Pharm from Gujarat Technological university in 2012 (with English).