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The purpose of the book is to develop and characterize pulsatile drug delivery system of a novel drug Dofetilide. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. Sodium starch glycollate, cross povidone and cross carmellose sodium were the super disintegrants used in core tablet formulation. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. The compression coating was done by using Eudragit S 100, Eudragit L 100 and ethyl cellulose as coating polymers. The maximum drug release data obtained by using combination of polymers in the ratio of 1:1. This book definitely will be useful for the researchers who wish to design and fabricate pulsatile drug delivery system for better therapeutic outcome.