Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery

Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery

Nitrendipin Self-Microemulsifying Drug Delivery System

Versandkostenfrei!
Versandfertig in 6-10 Tagen
29,99 €
inkl. MwSt.
PAYBACK Punkte
15 °P sammeln!
Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zet...