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Depression is one of the most worrying health problems worldwide and in Cuba, being considered a silent epidemic, with impact in other sectors, that is why the present research is aimed at offering a Multimedia proposal as a support alternative that contributes to minimize and/or prevent the manifestations of depression in adolescents with Systemic Lupus Erythematosus treated at the Rheumatology Service of the Pediatric Hospital of Villa Clara. The research was carried out with the purpose of providing more information and knowledge, especially to adolescents, about the manifestations of depression and to offer support tools.