Vishwas G. Pangarkar
Design of Multiphase Reactors
Vishwas G. Pangarkar
Design of Multiphase Reactors
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Details simple design methods for multiphase reactors in the chemical process industries
Includes basic aspects of transport in multiphase reactors and the importance of relatively reliable and simple procedures for predicting mass transfer parameters Details of design and scale up aspects of several important types of multiphase reactors Examples illustrated through design methodologies presenting different reactors for reactions that are industrially important Includes simple spreadsheet packages rather than complex algorithms / programs or computational aid
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Details simple design methods for multiphase reactors in the chemical process industries
Includes basic aspects of transport in multiphase reactors and the importance of relatively reliable and simple procedures for predicting mass transfer parameters
Details of design and scale up aspects of several important types of multiphase reactors
Examples illustrated through design methodologies presenting different reactors for reactions that are industrially important
Includes simple spreadsheet packages rather than complex algorithms / programs or computational aid
Includes basic aspects of transport in multiphase reactors and the importance of relatively reliable and simple procedures for predicting mass transfer parameters
Details of design and scale up aspects of several important types of multiphase reactors
Examples illustrated through design methodologies presenting different reactors for reactions that are industrially important
Includes simple spreadsheet packages rather than complex algorithms / programs or computational aid
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 536
- Erscheinungstermin: 27. Januar 2015
- Englisch
- Abmessung: 241mm x 159mm x 35mm
- Gewicht: 838g
- ISBN-13: 9781118807569
- ISBN-10: 1118807561
- Artikelnr.: 41078907
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 536
- Erscheinungstermin: 27. Januar 2015
- Englisch
- Abmessung: 241mm x 159mm x 35mm
- Gewicht: 838g
- ISBN-13: 9781118807569
- ISBN-10: 1118807561
- Artikelnr.: 41078907
Vishwas Govind Pangarkar was Professor and head of the Chemical Engineering Department of the University Institute of Chemical Technology in Mumbai, India. He has been actively engaged as a consultant in the chemical industry since 1974 for both Indian and overseas companies. He is the (co)author of three books and over 130 professional papers. He is the only Indian winner of both Herdillia and NOCIL Awards of The Indian Institute of Chemical Engineers, which are for excellence in such diverse fields as basic research and industrial innovations.
Foreword xv Preface xvii 1 Evolution of the Chemical Industry and
Importance of Multiphase Reactors 1 1.1 Evolution of Chemical Process
Industries 1 1.2 Sustainable and Green Processing Requirements in the
Modern Chemical Industry 4 1.3 Catalysis 9 1.4 Parameters Concerning
Catalyst Effectiveness in Industrial Operations 17 1.5 Importance of
Advanced Instrumental Techniques in Understanding Catalytic Phenomena 20
1.6 Role of Nanotechnology in Catalysis 21 1.7 Click Chemistry 21 1.8 Role
of Multiphase Reactors 22 References 23 2 Multiphase Reactors: The Design
and Scale-Up Problem 30 2.1 Introduction 30 2.2 The Scale-Up Conundrum 31
2.3 Intrinsic Kinetics: Invariance with Respect to Type/Size of Multiphase
Reactor 34 2.4 Transport Processes: Dependence on Type/Size of Multiphase
Reactor 34 2.5 Prediction of the Rate-Controlling Step in the Industrial
Reactor 35 2.6 Laboratory Methods for Discerning Intrinsic Kinetics of
Multiphase Reactions 35 Nomenclature 44 References 45 3 Multiphase
Reactors: Types and Criteria for Selection for a Given Application 47 3.1
Introduction to Simplified Design Philosophy 47 3.2 Classification of
Multiphase Reactors 48 3.3 Criteria for Reactor Selection 48 3.4 Some
Examples of Large-Scale Applications of Multiphase Reactors 55 Nomenclature
80 References 81 4 Turbulence: Fundamentals and Relevance to Multiphase
Reactors 87 4.1 Introduction 87 4.2 Fluid Turbulence 88 Nomenclature 91
References 91 5 Principles of Similarity and Their Application for Scale-Up
of Multiphase Reactors 93 5.1 Introduction to Principles of Similarity and
a Historic Perspective 93 5.2 States of Similarity of Relevance to Chemical
Process Equipments 94 Nomenclature 102 References 104 6 Mass Transfer in
Multiphase Reactors: Some Theoretical Considerations 106 6.1 Introduction
106 6.2 Purely Empirical Correlations Using Operating Parameters and
Physical Properties 107 6.3 Correlations Based on Mechanical Similarity 108
6.4 Correlations Based on Hydrodynamic/Turbulence Regime Similarity 116
Nomenclature 135 References 138 7A Stirred Tank Reactors for Chemical
Reactions 143 7A.1 Introduction 143 7A.1.1 The Standard Stirred Tank 143
7A.2 Power Requirements of Different Impellers 147 7A.3 Hydrodynamic
Regimes in Two-Phase (Gas-Liquid) Stirred Tank Reactors 148 7A.3.1 Constant
Speed of Agitation 150 7A.3.2 Constant Gas Flow Rate 150 7A.4 Hydrodynamic
Regimes in Three-Phase (Gas-Liquid-Solid) Stirred Tank Reactors 153 7A.5
Gas Holdup in Stirred Tank Reactors 155 7A.5.1 Some Basic Considerations
155 7A.5.2 Correlations for Gas Holdup 164 7A.5.3 Relative Gas Dispersion
(N/NCD) as a Correlating Parameter for Gas Holdup 165 7A.5.4 Correlations
for NCD 166 7A.6 Gas-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 166 7A.7 Solid-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 175 7A.7.1 Solid Suspension in Stirred Tank Reactor 175 7A.7.2
Correlations for Solid-Liquid Mass Transfer Coefficient 191 7A.8 Design of
Stirred Tank Reactors with Internal Cooling Coils 194 7A.8.1 Gas Holdup 194
7A.8.2 Critical Speed for Complete Dispersion of Gas 194 7A.8.3 Critical
Speed for Solid Suspension 195 7A.8.4 Gas-Liquid Mass Transfer Coefficient
195 7A.8.5 Solid-Liquid Mass Transfer Coefficient 196 7A.9 Stirred Tank
Reactor with Internal Draft Tube 196 7A.10 Worked Example: Design of
Stirred Reactor for Hydrogenation of Aniline to Cyclohexylamine (Capacity:
25000 Metric Tonnes per Year) 198 7A.10.1 Elucidation of the Output 201
Nomenclature 203 References 206 7B Stirred Tank Reactors for Cell Culture
Technology 216 7B.1 Introduction 216 7B.2 The Biopharmaceutical Process and
Cell Culture Engineering 224 7B.2.1 Animal Cell Culture vis-à-vis Microbial
Culture 224 7B.2.2 Major Improvements Related to Processing of Animal Cell
Culture 225 7B.2.3 Reactors for Large-Scale Animal Cell Culture 226 7B.3
Types of Bioreactors 229 7B.3.1 Major Components of Stirred Bioreactor 230
7B.4 Modes of Operation of Bioreactors 230 7B.4.1 Batch Mode 231 7B.4.2
Fed-Batch or Semibatch Mode 232 7B.4.3 Continuous Mode (Perfusion) 233 7B.5
Cell Retention Techniques for Use in Continuous Operation in Suspended Cell
Perfusion Processes 233 7B.5.1 Cell Retention Based on Size: Different
Types of Filtration Techniques 234 7B.5.2 Separation Based on Body Force
Difference 242 7B.5.3 Acoustic Devices 246 7B.6 Types of Cells and Modes of
Growth 253 7B.7 Growth Phases of Cells 254 7B.8 The Cell and Its Viability
in Bioreactors 256 7B.8.1 Shear Sensitivity 256 7B.9 Hydrodynamics 264
7B.9.1 Mixing in Bioreactors 264 7B.10 Gas Dispersion 273 7B.10.1
Importance of Gas Dispersion 273 7B.10.2 Effect of Dissolved Carbon Dioxide
on Bioprocess Rate 275 7B.10.3 Factors That Affect Gas Dispersion 277
7B.10.4 Estimation of NCD 278 7B.11 Solid Suspension 279 7B.11.1 Two-Phase
(Solid-Liquid) Systems 279 7B.11.2 Three-Phase (Gas-Liquid-Solid) Systems
280 7B.12 Mass Transfer 281 7B.12.1 Fractional Gas Holdup (µG) 281 7B.12.2
Gas-Liquid Mass Transfer 281 7B.12.3 Liquid-Cell Mass Transfer 283 7B.13
Foaming in Cell Culture Systems: Effects on Hydrodynamics and Mass Transfer
285 7B.14 Heat Transfer in Stirred Bioreactors 287 7B.15 Worked Cell
Culture Reactor Design Example 291 7B.15.1 Conventional Batch Stirred
Reactor with Air Sparging for Microcarrier-Supported Cells: A Simple Design
Methodology for Discerning the Rate-Controlling Step 291 7B.15.2 Reactor
Using Membrane-Based Oxygen Transfer 294 7B.15.3 Heat Transfer Area
Required 294 7B.16 Special Aspects of Stirred Bioreactor Design 295 7B.16.1
The Reactor Vessel 296 7B.16.2 Sterilizing System 296 7B.16.3 Measurement
Probes 296 7B.16.4 Agitator Seals 297 7B.16.5 Gasket and O-Ring Materials
297 7B.16.6 Vent Gas System 297 7B.16.7 Cell Retention Systems in Perfusion
Culture 297 7B.17 Concluding Remarks 298 Nomenclature 298 References 301 8
Venturi Loop Reactor 317 8.1 Introduction 317 8.2 Application Areas for the
Venturi Loop Reactor 317 8.3 Advantages of the Venturi Loop Reactor: A
Detailed Comparison 323 8.4 The Ejector-Based Liquid Jet Venturi Loop
Reactor 326 8.5 The Ejector-Diffuser System and Its Components 332 8.6
Hydrodynamics of Liquid Jet Ejector 333 8.7 Design of Venturi Loop Reactor
358 8.8 Solid Suspension in Venturi Loop Reactor 385 8.9 Solid-Liquid Mass
Transfer 388 8.10 Holding Vessel Size 389 8.11 Recommended Overall
Configuration 389 8.12 Scale-Up of Venturi Loop Reactor 390 8.13 Worked
Examples for Design of Venturi Loop Reactor: Hydrogenation of Aniline to
Cyclohexylamine 390 Nomenclature 395 References 399 9 Gas-Inducing Reactors
407 9.1 Introduction and Application Areas of Gas-Inducing Reactors 407 9.2
Mechanism of Gas Induction 409 9.3 Classification of Gas-Inducing Impellers
410 9.4 Multiple-Impeller Systems Using 2-2 Type Impeller for Gas Induction
429 9.5 Worked Example: Design of Gas-Inducing System with Multiple
Impellers for Hydrogenation of Aniline to Cyclohexylamine (Capacity: 25000
Metric Tonnes per Year) 441 Respectively) 441 Nomenclature 443 References
446 10 Two- and Three-Phase Sparged Reactors 451 10.1 Introduction 451 10.2
Hydrodynamic Regimes in TPSR 452 10.3 Gas Holdup 457 10.4 Solid-Liquid Mass
Transfer Coefficient (KSL) 466 10.5 Gas-Liquid Mass Transfer Coefficient
(kLa) 468 10.6 Axial Dispersion 472 10.7 Comments on Scale-Up of
TPSR/Bubble Columns 474 10.8 Reactor Design Example for Fischer-Tropsch
Synthesis Reactor 474 10.9 TPSR (Loop) with Internal Draft Tube (BCDT) 481
Nomenclature 493 References 496 Index 505
Importance of Multiphase Reactors 1 1.1 Evolution of Chemical Process
Industries 1 1.2 Sustainable and Green Processing Requirements in the
Modern Chemical Industry 4 1.3 Catalysis 9 1.4 Parameters Concerning
Catalyst Effectiveness in Industrial Operations 17 1.5 Importance of
Advanced Instrumental Techniques in Understanding Catalytic Phenomena 20
1.6 Role of Nanotechnology in Catalysis 21 1.7 Click Chemistry 21 1.8 Role
of Multiphase Reactors 22 References 23 2 Multiphase Reactors: The Design
and Scale-Up Problem 30 2.1 Introduction 30 2.2 The Scale-Up Conundrum 31
2.3 Intrinsic Kinetics: Invariance with Respect to Type/Size of Multiphase
Reactor 34 2.4 Transport Processes: Dependence on Type/Size of Multiphase
Reactor 34 2.5 Prediction of the Rate-Controlling Step in the Industrial
Reactor 35 2.6 Laboratory Methods for Discerning Intrinsic Kinetics of
Multiphase Reactions 35 Nomenclature 44 References 45 3 Multiphase
Reactors: Types and Criteria for Selection for a Given Application 47 3.1
Introduction to Simplified Design Philosophy 47 3.2 Classification of
Multiphase Reactors 48 3.3 Criteria for Reactor Selection 48 3.4 Some
Examples of Large-Scale Applications of Multiphase Reactors 55 Nomenclature
80 References 81 4 Turbulence: Fundamentals and Relevance to Multiphase
Reactors 87 4.1 Introduction 87 4.2 Fluid Turbulence 88 Nomenclature 91
References 91 5 Principles of Similarity and Their Application for Scale-Up
of Multiphase Reactors 93 5.1 Introduction to Principles of Similarity and
a Historic Perspective 93 5.2 States of Similarity of Relevance to Chemical
Process Equipments 94 Nomenclature 102 References 104 6 Mass Transfer in
Multiphase Reactors: Some Theoretical Considerations 106 6.1 Introduction
106 6.2 Purely Empirical Correlations Using Operating Parameters and
Physical Properties 107 6.3 Correlations Based on Mechanical Similarity 108
6.4 Correlations Based on Hydrodynamic/Turbulence Regime Similarity 116
Nomenclature 135 References 138 7A Stirred Tank Reactors for Chemical
Reactions 143 7A.1 Introduction 143 7A.1.1 The Standard Stirred Tank 143
7A.2 Power Requirements of Different Impellers 147 7A.3 Hydrodynamic
Regimes in Two-Phase (Gas-Liquid) Stirred Tank Reactors 148 7A.3.1 Constant
Speed of Agitation 150 7A.3.2 Constant Gas Flow Rate 150 7A.4 Hydrodynamic
Regimes in Three-Phase (Gas-Liquid-Solid) Stirred Tank Reactors 153 7A.5
Gas Holdup in Stirred Tank Reactors 155 7A.5.1 Some Basic Considerations
155 7A.5.2 Correlations for Gas Holdup 164 7A.5.3 Relative Gas Dispersion
(N/NCD) as a Correlating Parameter for Gas Holdup 165 7A.5.4 Correlations
for NCD 166 7A.6 Gas-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 166 7A.7 Solid-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 175 7A.7.1 Solid Suspension in Stirred Tank Reactor 175 7A.7.2
Correlations for Solid-Liquid Mass Transfer Coefficient 191 7A.8 Design of
Stirred Tank Reactors with Internal Cooling Coils 194 7A.8.1 Gas Holdup 194
7A.8.2 Critical Speed for Complete Dispersion of Gas 194 7A.8.3 Critical
Speed for Solid Suspension 195 7A.8.4 Gas-Liquid Mass Transfer Coefficient
195 7A.8.5 Solid-Liquid Mass Transfer Coefficient 196 7A.9 Stirred Tank
Reactor with Internal Draft Tube 196 7A.10 Worked Example: Design of
Stirred Reactor for Hydrogenation of Aniline to Cyclohexylamine (Capacity:
25000 Metric Tonnes per Year) 198 7A.10.1 Elucidation of the Output 201
Nomenclature 203 References 206 7B Stirred Tank Reactors for Cell Culture
Technology 216 7B.1 Introduction 216 7B.2 The Biopharmaceutical Process and
Cell Culture Engineering 224 7B.2.1 Animal Cell Culture vis-à-vis Microbial
Culture 224 7B.2.2 Major Improvements Related to Processing of Animal Cell
Culture 225 7B.2.3 Reactors for Large-Scale Animal Cell Culture 226 7B.3
Types of Bioreactors 229 7B.3.1 Major Components of Stirred Bioreactor 230
7B.4 Modes of Operation of Bioreactors 230 7B.4.1 Batch Mode 231 7B.4.2
Fed-Batch or Semibatch Mode 232 7B.4.3 Continuous Mode (Perfusion) 233 7B.5
Cell Retention Techniques for Use in Continuous Operation in Suspended Cell
Perfusion Processes 233 7B.5.1 Cell Retention Based on Size: Different
Types of Filtration Techniques 234 7B.5.2 Separation Based on Body Force
Difference 242 7B.5.3 Acoustic Devices 246 7B.6 Types of Cells and Modes of
Growth 253 7B.7 Growth Phases of Cells 254 7B.8 The Cell and Its Viability
in Bioreactors 256 7B.8.1 Shear Sensitivity 256 7B.9 Hydrodynamics 264
7B.9.1 Mixing in Bioreactors 264 7B.10 Gas Dispersion 273 7B.10.1
Importance of Gas Dispersion 273 7B.10.2 Effect of Dissolved Carbon Dioxide
on Bioprocess Rate 275 7B.10.3 Factors That Affect Gas Dispersion 277
7B.10.4 Estimation of NCD 278 7B.11 Solid Suspension 279 7B.11.1 Two-Phase
(Solid-Liquid) Systems 279 7B.11.2 Three-Phase (Gas-Liquid-Solid) Systems
280 7B.12 Mass Transfer 281 7B.12.1 Fractional Gas Holdup (µG) 281 7B.12.2
Gas-Liquid Mass Transfer 281 7B.12.3 Liquid-Cell Mass Transfer 283 7B.13
Foaming in Cell Culture Systems: Effects on Hydrodynamics and Mass Transfer
285 7B.14 Heat Transfer in Stirred Bioreactors 287 7B.15 Worked Cell
Culture Reactor Design Example 291 7B.15.1 Conventional Batch Stirred
Reactor with Air Sparging for Microcarrier-Supported Cells: A Simple Design
Methodology for Discerning the Rate-Controlling Step 291 7B.15.2 Reactor
Using Membrane-Based Oxygen Transfer 294 7B.15.3 Heat Transfer Area
Required 294 7B.16 Special Aspects of Stirred Bioreactor Design 295 7B.16.1
The Reactor Vessel 296 7B.16.2 Sterilizing System 296 7B.16.3 Measurement
Probes 296 7B.16.4 Agitator Seals 297 7B.16.5 Gasket and O-Ring Materials
297 7B.16.6 Vent Gas System 297 7B.16.7 Cell Retention Systems in Perfusion
Culture 297 7B.17 Concluding Remarks 298 Nomenclature 298 References 301 8
Venturi Loop Reactor 317 8.1 Introduction 317 8.2 Application Areas for the
Venturi Loop Reactor 317 8.3 Advantages of the Venturi Loop Reactor: A
Detailed Comparison 323 8.4 The Ejector-Based Liquid Jet Venturi Loop
Reactor 326 8.5 The Ejector-Diffuser System and Its Components 332 8.6
Hydrodynamics of Liquid Jet Ejector 333 8.7 Design of Venturi Loop Reactor
358 8.8 Solid Suspension in Venturi Loop Reactor 385 8.9 Solid-Liquid Mass
Transfer 388 8.10 Holding Vessel Size 389 8.11 Recommended Overall
Configuration 389 8.12 Scale-Up of Venturi Loop Reactor 390 8.13 Worked
Examples for Design of Venturi Loop Reactor: Hydrogenation of Aniline to
Cyclohexylamine 390 Nomenclature 395 References 399 9 Gas-Inducing Reactors
407 9.1 Introduction and Application Areas of Gas-Inducing Reactors 407 9.2
Mechanism of Gas Induction 409 9.3 Classification of Gas-Inducing Impellers
410 9.4 Multiple-Impeller Systems Using 2-2 Type Impeller for Gas Induction
429 9.5 Worked Example: Design of Gas-Inducing System with Multiple
Impellers for Hydrogenation of Aniline to Cyclohexylamine (Capacity: 25000
Metric Tonnes per Year) 441 Respectively) 441 Nomenclature 443 References
446 10 Two- and Three-Phase Sparged Reactors 451 10.1 Introduction 451 10.2
Hydrodynamic Regimes in TPSR 452 10.3 Gas Holdup 457 10.4 Solid-Liquid Mass
Transfer Coefficient (KSL) 466 10.5 Gas-Liquid Mass Transfer Coefficient
(kLa) 468 10.6 Axial Dispersion 472 10.7 Comments on Scale-Up of
TPSR/Bubble Columns 474 10.8 Reactor Design Example for Fischer-Tropsch
Synthesis Reactor 474 10.9 TPSR (Loop) with Internal Draft Tube (BCDT) 481
Nomenclature 493 References 496 Index 505
Foreword xv Preface xvii 1 Evolution of the Chemical Industry and
Importance of Multiphase Reactors 1 1.1 Evolution of Chemical Process
Industries 1 1.2 Sustainable and Green Processing Requirements in the
Modern Chemical Industry 4 1.3 Catalysis 9 1.4 Parameters Concerning
Catalyst Effectiveness in Industrial Operations 17 1.5 Importance of
Advanced Instrumental Techniques in Understanding Catalytic Phenomena 20
1.6 Role of Nanotechnology in Catalysis 21 1.7 Click Chemistry 21 1.8 Role
of Multiphase Reactors 22 References 23 2 Multiphase Reactors: The Design
and Scale-Up Problem 30 2.1 Introduction 30 2.2 The Scale-Up Conundrum 31
2.3 Intrinsic Kinetics: Invariance with Respect to Type/Size of Multiphase
Reactor 34 2.4 Transport Processes: Dependence on Type/Size of Multiphase
Reactor 34 2.5 Prediction of the Rate-Controlling Step in the Industrial
Reactor 35 2.6 Laboratory Methods for Discerning Intrinsic Kinetics of
Multiphase Reactions 35 Nomenclature 44 References 45 3 Multiphase
Reactors: Types and Criteria for Selection for a Given Application 47 3.1
Introduction to Simplified Design Philosophy 47 3.2 Classification of
Multiphase Reactors 48 3.3 Criteria for Reactor Selection 48 3.4 Some
Examples of Large-Scale Applications of Multiphase Reactors 55 Nomenclature
80 References 81 4 Turbulence: Fundamentals and Relevance to Multiphase
Reactors 87 4.1 Introduction 87 4.2 Fluid Turbulence 88 Nomenclature 91
References 91 5 Principles of Similarity and Their Application for Scale-Up
of Multiphase Reactors 93 5.1 Introduction to Principles of Similarity and
a Historic Perspective 93 5.2 States of Similarity of Relevance to Chemical
Process Equipments 94 Nomenclature 102 References 104 6 Mass Transfer in
Multiphase Reactors: Some Theoretical Considerations 106 6.1 Introduction
106 6.2 Purely Empirical Correlations Using Operating Parameters and
Physical Properties 107 6.3 Correlations Based on Mechanical Similarity 108
6.4 Correlations Based on Hydrodynamic/Turbulence Regime Similarity 116
Nomenclature 135 References 138 7A Stirred Tank Reactors for Chemical
Reactions 143 7A.1 Introduction 143 7A.1.1 The Standard Stirred Tank 143
7A.2 Power Requirements of Different Impellers 147 7A.3 Hydrodynamic
Regimes in Two-Phase (Gas-Liquid) Stirred Tank Reactors 148 7A.3.1 Constant
Speed of Agitation 150 7A.3.2 Constant Gas Flow Rate 150 7A.4 Hydrodynamic
Regimes in Three-Phase (Gas-Liquid-Solid) Stirred Tank Reactors 153 7A.5
Gas Holdup in Stirred Tank Reactors 155 7A.5.1 Some Basic Considerations
155 7A.5.2 Correlations for Gas Holdup 164 7A.5.3 Relative Gas Dispersion
(N/NCD) as a Correlating Parameter for Gas Holdup 165 7A.5.4 Correlations
for NCD 166 7A.6 Gas-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 166 7A.7 Solid-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 175 7A.7.1 Solid Suspension in Stirred Tank Reactor 175 7A.7.2
Correlations for Solid-Liquid Mass Transfer Coefficient 191 7A.8 Design of
Stirred Tank Reactors with Internal Cooling Coils 194 7A.8.1 Gas Holdup 194
7A.8.2 Critical Speed for Complete Dispersion of Gas 194 7A.8.3 Critical
Speed for Solid Suspension 195 7A.8.4 Gas-Liquid Mass Transfer Coefficient
195 7A.8.5 Solid-Liquid Mass Transfer Coefficient 196 7A.9 Stirred Tank
Reactor with Internal Draft Tube 196 7A.10 Worked Example: Design of
Stirred Reactor for Hydrogenation of Aniline to Cyclohexylamine (Capacity:
25000 Metric Tonnes per Year) 198 7A.10.1 Elucidation of the Output 201
Nomenclature 203 References 206 7B Stirred Tank Reactors for Cell Culture
Technology 216 7B.1 Introduction 216 7B.2 The Biopharmaceutical Process and
Cell Culture Engineering 224 7B.2.1 Animal Cell Culture vis-à-vis Microbial
Culture 224 7B.2.2 Major Improvements Related to Processing of Animal Cell
Culture 225 7B.2.3 Reactors for Large-Scale Animal Cell Culture 226 7B.3
Types of Bioreactors 229 7B.3.1 Major Components of Stirred Bioreactor 230
7B.4 Modes of Operation of Bioreactors 230 7B.4.1 Batch Mode 231 7B.4.2
Fed-Batch or Semibatch Mode 232 7B.4.3 Continuous Mode (Perfusion) 233 7B.5
Cell Retention Techniques for Use in Continuous Operation in Suspended Cell
Perfusion Processes 233 7B.5.1 Cell Retention Based on Size: Different
Types of Filtration Techniques 234 7B.5.2 Separation Based on Body Force
Difference 242 7B.5.3 Acoustic Devices 246 7B.6 Types of Cells and Modes of
Growth 253 7B.7 Growth Phases of Cells 254 7B.8 The Cell and Its Viability
in Bioreactors 256 7B.8.1 Shear Sensitivity 256 7B.9 Hydrodynamics 264
7B.9.1 Mixing in Bioreactors 264 7B.10 Gas Dispersion 273 7B.10.1
Importance of Gas Dispersion 273 7B.10.2 Effect of Dissolved Carbon Dioxide
on Bioprocess Rate 275 7B.10.3 Factors That Affect Gas Dispersion 277
7B.10.4 Estimation of NCD 278 7B.11 Solid Suspension 279 7B.11.1 Two-Phase
(Solid-Liquid) Systems 279 7B.11.2 Three-Phase (Gas-Liquid-Solid) Systems
280 7B.12 Mass Transfer 281 7B.12.1 Fractional Gas Holdup (µG) 281 7B.12.2
Gas-Liquid Mass Transfer 281 7B.12.3 Liquid-Cell Mass Transfer 283 7B.13
Foaming in Cell Culture Systems: Effects on Hydrodynamics and Mass Transfer
285 7B.14 Heat Transfer in Stirred Bioreactors 287 7B.15 Worked Cell
Culture Reactor Design Example 291 7B.15.1 Conventional Batch Stirred
Reactor with Air Sparging for Microcarrier-Supported Cells: A Simple Design
Methodology for Discerning the Rate-Controlling Step 291 7B.15.2 Reactor
Using Membrane-Based Oxygen Transfer 294 7B.15.3 Heat Transfer Area
Required 294 7B.16 Special Aspects of Stirred Bioreactor Design 295 7B.16.1
The Reactor Vessel 296 7B.16.2 Sterilizing System 296 7B.16.3 Measurement
Probes 296 7B.16.4 Agitator Seals 297 7B.16.5 Gasket and O-Ring Materials
297 7B.16.6 Vent Gas System 297 7B.16.7 Cell Retention Systems in Perfusion
Culture 297 7B.17 Concluding Remarks 298 Nomenclature 298 References 301 8
Venturi Loop Reactor 317 8.1 Introduction 317 8.2 Application Areas for the
Venturi Loop Reactor 317 8.3 Advantages of the Venturi Loop Reactor: A
Detailed Comparison 323 8.4 The Ejector-Based Liquid Jet Venturi Loop
Reactor 326 8.5 The Ejector-Diffuser System and Its Components 332 8.6
Hydrodynamics of Liquid Jet Ejector 333 8.7 Design of Venturi Loop Reactor
358 8.8 Solid Suspension in Venturi Loop Reactor 385 8.9 Solid-Liquid Mass
Transfer 388 8.10 Holding Vessel Size 389 8.11 Recommended Overall
Configuration 389 8.12 Scale-Up of Venturi Loop Reactor 390 8.13 Worked
Examples for Design of Venturi Loop Reactor: Hydrogenation of Aniline to
Cyclohexylamine 390 Nomenclature 395 References 399 9 Gas-Inducing Reactors
407 9.1 Introduction and Application Areas of Gas-Inducing Reactors 407 9.2
Mechanism of Gas Induction 409 9.3 Classification of Gas-Inducing Impellers
410 9.4 Multiple-Impeller Systems Using 2-2 Type Impeller for Gas Induction
429 9.5 Worked Example: Design of Gas-Inducing System with Multiple
Impellers for Hydrogenation of Aniline to Cyclohexylamine (Capacity: 25000
Metric Tonnes per Year) 441 Respectively) 441 Nomenclature 443 References
446 10 Two- and Three-Phase Sparged Reactors 451 10.1 Introduction 451 10.2
Hydrodynamic Regimes in TPSR 452 10.3 Gas Holdup 457 10.4 Solid-Liquid Mass
Transfer Coefficient (KSL) 466 10.5 Gas-Liquid Mass Transfer Coefficient
(kLa) 468 10.6 Axial Dispersion 472 10.7 Comments on Scale-Up of
TPSR/Bubble Columns 474 10.8 Reactor Design Example for Fischer-Tropsch
Synthesis Reactor 474 10.9 TPSR (Loop) with Internal Draft Tube (BCDT) 481
Nomenclature 493 References 496 Index 505
Importance of Multiphase Reactors 1 1.1 Evolution of Chemical Process
Industries 1 1.2 Sustainable and Green Processing Requirements in the
Modern Chemical Industry 4 1.3 Catalysis 9 1.4 Parameters Concerning
Catalyst Effectiveness in Industrial Operations 17 1.5 Importance of
Advanced Instrumental Techniques in Understanding Catalytic Phenomena 20
1.6 Role of Nanotechnology in Catalysis 21 1.7 Click Chemistry 21 1.8 Role
of Multiphase Reactors 22 References 23 2 Multiphase Reactors: The Design
and Scale-Up Problem 30 2.1 Introduction 30 2.2 The Scale-Up Conundrum 31
2.3 Intrinsic Kinetics: Invariance with Respect to Type/Size of Multiphase
Reactor 34 2.4 Transport Processes: Dependence on Type/Size of Multiphase
Reactor 34 2.5 Prediction of the Rate-Controlling Step in the Industrial
Reactor 35 2.6 Laboratory Methods for Discerning Intrinsic Kinetics of
Multiphase Reactions 35 Nomenclature 44 References 45 3 Multiphase
Reactors: Types and Criteria for Selection for a Given Application 47 3.1
Introduction to Simplified Design Philosophy 47 3.2 Classification of
Multiphase Reactors 48 3.3 Criteria for Reactor Selection 48 3.4 Some
Examples of Large-Scale Applications of Multiphase Reactors 55 Nomenclature
80 References 81 4 Turbulence: Fundamentals and Relevance to Multiphase
Reactors 87 4.1 Introduction 87 4.2 Fluid Turbulence 88 Nomenclature 91
References 91 5 Principles of Similarity and Their Application for Scale-Up
of Multiphase Reactors 93 5.1 Introduction to Principles of Similarity and
a Historic Perspective 93 5.2 States of Similarity of Relevance to Chemical
Process Equipments 94 Nomenclature 102 References 104 6 Mass Transfer in
Multiphase Reactors: Some Theoretical Considerations 106 6.1 Introduction
106 6.2 Purely Empirical Correlations Using Operating Parameters and
Physical Properties 107 6.3 Correlations Based on Mechanical Similarity 108
6.4 Correlations Based on Hydrodynamic/Turbulence Regime Similarity 116
Nomenclature 135 References 138 7A Stirred Tank Reactors for Chemical
Reactions 143 7A.1 Introduction 143 7A.1.1 The Standard Stirred Tank 143
7A.2 Power Requirements of Different Impellers 147 7A.3 Hydrodynamic
Regimes in Two-Phase (Gas-Liquid) Stirred Tank Reactors 148 7A.3.1 Constant
Speed of Agitation 150 7A.3.2 Constant Gas Flow Rate 150 7A.4 Hydrodynamic
Regimes in Three-Phase (Gas-Liquid-Solid) Stirred Tank Reactors 153 7A.5
Gas Holdup in Stirred Tank Reactors 155 7A.5.1 Some Basic Considerations
155 7A.5.2 Correlations for Gas Holdup 164 7A.5.3 Relative Gas Dispersion
(N/NCD) as a Correlating Parameter for Gas Holdup 165 7A.5.4 Correlations
for NCD 166 7A.6 Gas-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 166 7A.7 Solid-Liquid Mass Transfer Coefficient in Stirred Tank
Reactor 175 7A.7.1 Solid Suspension in Stirred Tank Reactor 175 7A.7.2
Correlations for Solid-Liquid Mass Transfer Coefficient 191 7A.8 Design of
Stirred Tank Reactors with Internal Cooling Coils 194 7A.8.1 Gas Holdup 194
7A.8.2 Critical Speed for Complete Dispersion of Gas 194 7A.8.3 Critical
Speed for Solid Suspension 195 7A.8.4 Gas-Liquid Mass Transfer Coefficient
195 7A.8.5 Solid-Liquid Mass Transfer Coefficient 196 7A.9 Stirred Tank
Reactor with Internal Draft Tube 196 7A.10 Worked Example: Design of
Stirred Reactor for Hydrogenation of Aniline to Cyclohexylamine (Capacity:
25000 Metric Tonnes per Year) 198 7A.10.1 Elucidation of the Output 201
Nomenclature 203 References 206 7B Stirred Tank Reactors for Cell Culture
Technology 216 7B.1 Introduction 216 7B.2 The Biopharmaceutical Process and
Cell Culture Engineering 224 7B.2.1 Animal Cell Culture vis-à-vis Microbial
Culture 224 7B.2.2 Major Improvements Related to Processing of Animal Cell
Culture 225 7B.2.3 Reactors for Large-Scale Animal Cell Culture 226 7B.3
Types of Bioreactors 229 7B.3.1 Major Components of Stirred Bioreactor 230
7B.4 Modes of Operation of Bioreactors 230 7B.4.1 Batch Mode 231 7B.4.2
Fed-Batch or Semibatch Mode 232 7B.4.3 Continuous Mode (Perfusion) 233 7B.5
Cell Retention Techniques for Use in Continuous Operation in Suspended Cell
Perfusion Processes 233 7B.5.1 Cell Retention Based on Size: Different
Types of Filtration Techniques 234 7B.5.2 Separation Based on Body Force
Difference 242 7B.5.3 Acoustic Devices 246 7B.6 Types of Cells and Modes of
Growth 253 7B.7 Growth Phases of Cells 254 7B.8 The Cell and Its Viability
in Bioreactors 256 7B.8.1 Shear Sensitivity 256 7B.9 Hydrodynamics 264
7B.9.1 Mixing in Bioreactors 264 7B.10 Gas Dispersion 273 7B.10.1
Importance of Gas Dispersion 273 7B.10.2 Effect of Dissolved Carbon Dioxide
on Bioprocess Rate 275 7B.10.3 Factors That Affect Gas Dispersion 277
7B.10.4 Estimation of NCD 278 7B.11 Solid Suspension 279 7B.11.1 Two-Phase
(Solid-Liquid) Systems 279 7B.11.2 Three-Phase (Gas-Liquid-Solid) Systems
280 7B.12 Mass Transfer 281 7B.12.1 Fractional Gas Holdup (µG) 281 7B.12.2
Gas-Liquid Mass Transfer 281 7B.12.3 Liquid-Cell Mass Transfer 283 7B.13
Foaming in Cell Culture Systems: Effects on Hydrodynamics and Mass Transfer
285 7B.14 Heat Transfer in Stirred Bioreactors 287 7B.15 Worked Cell
Culture Reactor Design Example 291 7B.15.1 Conventional Batch Stirred
Reactor with Air Sparging for Microcarrier-Supported Cells: A Simple Design
Methodology for Discerning the Rate-Controlling Step 291 7B.15.2 Reactor
Using Membrane-Based Oxygen Transfer 294 7B.15.3 Heat Transfer Area
Required 294 7B.16 Special Aspects of Stirred Bioreactor Design 295 7B.16.1
The Reactor Vessel 296 7B.16.2 Sterilizing System 296 7B.16.3 Measurement
Probes 296 7B.16.4 Agitator Seals 297 7B.16.5 Gasket and O-Ring Materials
297 7B.16.6 Vent Gas System 297 7B.16.7 Cell Retention Systems in Perfusion
Culture 297 7B.17 Concluding Remarks 298 Nomenclature 298 References 301 8
Venturi Loop Reactor 317 8.1 Introduction 317 8.2 Application Areas for the
Venturi Loop Reactor 317 8.3 Advantages of the Venturi Loop Reactor: A
Detailed Comparison 323 8.4 The Ejector-Based Liquid Jet Venturi Loop
Reactor 326 8.5 The Ejector-Diffuser System and Its Components 332 8.6
Hydrodynamics of Liquid Jet Ejector 333 8.7 Design of Venturi Loop Reactor
358 8.8 Solid Suspension in Venturi Loop Reactor 385 8.9 Solid-Liquid Mass
Transfer 388 8.10 Holding Vessel Size 389 8.11 Recommended Overall
Configuration 389 8.12 Scale-Up of Venturi Loop Reactor 390 8.13 Worked
Examples for Design of Venturi Loop Reactor: Hydrogenation of Aniline to
Cyclohexylamine 390 Nomenclature 395 References 399 9 Gas-Inducing Reactors
407 9.1 Introduction and Application Areas of Gas-Inducing Reactors 407 9.2
Mechanism of Gas Induction 409 9.3 Classification of Gas-Inducing Impellers
410 9.4 Multiple-Impeller Systems Using 2-2 Type Impeller for Gas Induction
429 9.5 Worked Example: Design of Gas-Inducing System with Multiple
Impellers for Hydrogenation of Aniline to Cyclohexylamine (Capacity: 25000
Metric Tonnes per Year) 441 Respectively) 441 Nomenclature 443 References
446 10 Two- and Three-Phase Sparged Reactors 451 10.1 Introduction 451 10.2
Hydrodynamic Regimes in TPSR 452 10.3 Gas Holdup 457 10.4 Solid-Liquid Mass
Transfer Coefficient (KSL) 466 10.5 Gas-Liquid Mass Transfer Coefficient
(kLa) 468 10.6 Axial Dispersion 472 10.7 Comments on Scale-Up of
TPSR/Bubble Columns 474 10.8 Reactor Design Example for Fischer-Tropsch
Synthesis Reactor 474 10.9 TPSR (Loop) with Internal Draft Tube (BCDT) 481
Nomenclature 493 References 496 Index 505