DESIGN OF OSMOTIC CONTROLLED DRUG DELIVERY SYSTEM - Misra, Ambikanandan;Kanagale, Pritam D.
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Osmotic systems, one of the oral dosage form utilize the principles of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameters and it is also possible to modulate the release characteristics by optimizing the properties of drug and system. The aim of present research was to design and optimize the three novel osmotic drug delivery systems viz. Swellable Porous Osmotic System (SPOP), Monolithic Osmotic Tablet System (MOTS) & Controlled Porosity Osmotic System (CPOP) for water soluble and low water soluble drugs and…mehr

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Produktbeschreibung
Osmotic systems, one of the oral dosage form utilize the principles of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameters and it is also possible to modulate the release characteristics by optimizing the properties of drug and system. The aim of present research was to design and optimize the three novel osmotic drug delivery systems viz. Swellable Porous Osmotic System (SPOP), Monolithic Osmotic Tablet System (MOTS) & Controlled Porosity Osmotic System (CPOP) for water soluble and low water soluble drugs and compare principle and methodology of CR design. Extended release formulations of Venlafaxine HCl and Glipizide were developed based on SPOP technology. Extended release formulations of Metoprolol Tartrate and Nifedipine were developed based on MOTS technology. Extended release formulations of Oxybutynin chloride and Atenolol were developed based on CPOP technology. Based on the present work it is clear that extended release formulations of drugs having different solubility profile can be developed using these technologies. The in-vivo pharmacokinetic study in beagle dog confirmed the same.
Autorenporträt
Ambikanandan Misra, PhD. Professor at Pharmacy Department, The Maharaja Sayajirao University of Baroda,Vadodara-01, India and Coordinator of Technology Information Forecasting Assessment Council¿s Center of Relevance and Excellence in New Drug Delivery Systems. Has over 30 years of both academic and industrial experience in Drug Delivery Research.