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The rapid development and understanding of the chemistry of molecular biology and amino acids have created a significant class of compounds that are now helpful in understanding biological functions of macromolecules like proteins. Schiff base complexes own a lot of activities against bacteria, fungi, and certain types of tumor and they have been used as radiotracers in nuclear medicine and drugs. Many Schiff base complexes may serve as models for biologically important species and have extensive applications in the fields of medicine, photo and magnetic chemistry, and electrochemistry. Schiff base amino acid complexes act as good chelating agents and behave as efficient biologically active and cytotoxic agents. In addition, Schiff base amino acid complexes are considered to combine new kinds of potential antibacterial and anticancer reagents. Iron Schiff base complexes provide useful structural and electronic models for the similarly coordinated sites found in the heme iron enzymes and their structure and catalytic activity are analogous with those of iron porphyrins.