Design selective glutamate dehydrogenase inhibitors? - Song, Yunbo
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Plasmodium falciparum glutamate dehydrogenase (GDH) is an attractive target for the rational development of new antimalarial drugs. Enzyme Kinetics assays and molecular modelling technology were used to measure inhibition effects for some ligands on two different GDHs. The study presented in this work provided a base line for future explorations and discoveries of the inhibition selectivity between Plasmodium and human GDH based on bacterial and mammalian animal GDH.

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Produktbeschreibung
Plasmodium falciparum glutamate dehydrogenase (GDH) is an attractive target for the rational development of new antimalarial drugs. Enzyme Kinetics assays and molecular modelling technology were used to measure inhibition effects for some ligands on two different GDHs. The study presented in this work provided a base line for future explorations and discoveries of the inhibition selectivity between Plasmodium and human GDH based on bacterial and mammalian animal GDH.
Autorenporträt
Yunbo Song obtuvo la licenciatura en medicina en la Facultad de Odontología de la Universidad de Pekín (China) y una maestría en la Universidad Nacional de Irlanda en 2005, donde llevó a cabo el proyecto de investigación de este libro. A continuación, se doctoró en el programa de Neurociencia de la Universidad de Buffalo en EE.UU., y se espera que lo consiga en 2011.