Andere Kunden interessierten sich auch für
![Synthesis of Curcumin Analogues as Novel Anti Malarial Agents]( "Synthesis of Curcumin Analogues as Novel Anti Malarial Agents")
Synthesis of Curcumin Analogues as Novel Anti Malarial Agents29,99 €![Role of curcumin and its analogues in various diseases]( "Role of curcumin and its analogues in various diseases")
Role of curcumin and its analogues in various diseases29,99 €![Molecular properties prediction and synthesis of oxadiazole analogues]( "Molecular properties prediction and synthesis of oxadiazole analogues")
Molecular properties prediction and synthesis of oxadiazole analogues29,99 €![Design, Synthesis and Evaluation of Some Novel Heterocyclic Compounds]( "Design, Synthesis and Evaluation of Some Novel Heterocyclic Compounds")
Design, Synthesis and Evaluation of Some Novel Heterocyclic Compounds29,99 €![Design, Synthesis and Biological Evaluation of substituted Triazine]( "Design, Synthesis and Biological Evaluation of substituted Triazine")
Design, Synthesis and Biological Evaluation of substituted Triazine26,99 €![Design, and Synthesis of Novel Anti - tuberculosis Agents]( "Design, and Synthesis of Novel Anti - tuberculosis Agents")
Design, and Synthesis of Novel Anti - tuberculosis Agents64,99 €![Design, Synthesis and Evaluation of Small Molecules as ALK5 Inhibitors]( "Design, Synthesis and Evaluation of Small Molecules as ALK5 Inhibitors")
Design, Synthesis and Evaluation of Small Molecules as ALK5 Inhibitors29,99 €
A series of 11 curcumin analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for anti-HIV screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (3a-k) were evaluated for anti-HIV activity as per the standard protocol. Maximum drug-likeness model score (1.1.0) was found for 3,5-bis(4-hydroxy-3-methylstyryl)-N-(4-chlorophenyl)-1H-pyrazole-1-carboxamide (3b). The compound 3b was found to have anti-HIV activity with IC50 3.71 µM and CC50 3.71 µM, however the activity was found to be less than the standard drug zidovudine.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.