Ahmed Ibrahim, Sanaa Eissa

Detection of Methylated RAR in the Urine of Bladder Cancer Patients

Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine

• Broschiertes Buch

Produktbeschreibung

Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RAR 2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RAR 2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RAR 2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RAR 2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RAR 2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 248
• Erscheinungstermin: 26. Januar 2012
• Englisch
• Abmessung: 220mm x 150mm x 15mm
• Gewicht: 387g
• ISBN-13: 9783847379249
• ISBN-10: 3847379240
• Artikelnr.: 34903274

Autorenporträt

Les domaines de recherche du Dr Ahmed Osman Ibrahim sont les suivants : théorie et critique de l'architecture, architecture moderne et contemporaine, locale, régionale et internationale, pédagogie de l'enseignement de l'architecture, patrimoine urbain, attractions touristiques, emploi de matériaux de construction traditionnels dans l'architecture vernaculaire.