Diarrhea is one of the leading causes of morbidity and mortality among under-five children nationally and globally. In Ethiopia, prevalence of diarrhea among under-five children is 13%, and highest among children residing in households that drink from unprotected wells (18 %), those residing in rural areas (14%) and living in Benishangul-Gumuz (the study area) and Gambela Region. Acute diarrhea is influenced by factors from all hierarchical levels. Therefore, Avoiding bottle feeding and interpersonal transmission, strengthening women's education, improving child nutrition; maximizing the health extension package model households and treating water at home are recommended with more emphasis on rural living children. The book could be of paramount importance for an individual or institutions who is interested in medical or public health research, health care services, health workers, colleges, and universities to plan and take effective measures by focusing on risk-reduction and then reduce morbidity and mortality due to diarrhea among young children.