This book elaborates the Determinants of Commercial Banks' profitability in Ethiopia taking five bank specific variables namely:capital adequacy,bank size,asset composition,loan loss provision and liquidity and ROA and ROE were used to measure profitability.Ten years data(2003-2012) gathered from seven commercial banks(CBE,Awash,Dashen, Nib ,Wugagen,Abyssinia,United banks) were analyzed using descriptive ,correlation and regression analysis.