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The influence of personal and family factors on academic success in students of General Basic Education (EGB) and General Unified Baccalaureate (BGU) in Ecuador during the evaluation "Ser Estudiante (SEST) cycle 2020 - 2021" is analyzed. The SEST assessment evaluates knowledge, skills, abilities and attitudes of Ecuadorian students. It also deploys questionnaires of associated factors that construct social, cultural and economic variables of families, teachers and the environment of educational institutions. A two-level hierarchical linear model is used to measure the impact of the factors associated with school performance. In sum, personal and family environment factors, in which students develop, are elements that contribute to improve their school performance.