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In the present study, new kinetic spetcrophotometric method for determination of two antibiotics (cefadroxil and cefixime) using two natural reagents Henna (Lawsonia inermis Linnaeus) and Saffron (Crocus sativus Linnaeus) in bulk and pharmaceutical formulations. The used method for the determination of antibiotics (cefadroxil and cefixime) based on reaction of these antibiotics with different reagents.