Determination of Drugs using Capillary Electrophoresis - Al Azzam, Khaldun Mohammad Mitlaq;Saad, Bahruddin
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Capillary electrophoresis (CE) is slowly becoming a mainstream analytical technique. This book highlights several unique studies of CE for the determination of drugs. The lack of sensitivity of the CE technique is overcome by the use of an innovative liquid-phase microextraction technique for the trace determination of the anti-diabetic drug, rosiglitazone in biological fluids. For non-chromophoric compounds, the use of the capacitively coupled contactless conductivity detector offers an interesting option. This is demonstrated in the determination of the -blocker drugs (atenolol,…mehr

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Produktbeschreibung
Capillary electrophoresis (CE) is slowly becoming a mainstream analytical technique. This book highlights several unique studies of CE for the determination of drugs. The lack of sensitivity of the CE technique is overcome by the use of an innovative liquid-phase microextraction technique for the trace determination of the anti-diabetic drug, rosiglitazone in biological fluids. For non-chromophoric compounds, the use of the capacitively coupled contactless conductivity detector offers an interesting option. This is demonstrated in the determination of the -blocker drugs (atenolol, chlorthalidone and amiloride), the antiviral drugs acyclovir and valacyclovir and their major impurity (guanine) in pharmaceutical preparations. The separation of the enantiomers of both ofloxacin and ornidazole or modafinil are also described. The computational calculations for the enantiomeric inclusion complexes for a few of these drugs and binding constant measurements were also measured. This book will provide researchers, students, chemists, pharmacists, and scientists valuable insights into the fundamentals and applications of CE in drug analysis.
Autorenporträt
Dr. Khaldun Mohammad Mitlaq Al Azzam obtained his PhD in analytical chemistry in 2011 from the School of Chemical Sciences, Universiti Sains Malaysia (USM), Penang, Malaysia. Dr. Al Azzam is currently working as lecturer at the College of Pharmacy, Isra University, Amman, Jordan. Dr. Bahruddin Saad is a professor in analytical chemistry at USM.