This book is organized in five parts. In part one Cane Koteski explains natural geographic characteristics of east region in the republic of Macedonia.In the second part Zlatko Jakovlev describes Sport tourisam as the most important alternative form of tourism.In the part three Biljana Petrevska writes about tourism as a factor of contribution to the regional development: the case of east region of Macedonia.In the fourth part Aleksandra Zhezhova writes about the contemporary challenges of entrepreneurship and tourism communication achievements in function of modern tourism. In the last fifth part Mimoza Serafimova debates around entrepreneurship in Macedonia conditions and challenges.