The main aim of the study was to investigate the detriments associated with substance abuse among the out- of- school youth of Ntselamanzi Village in Alice. This study intended to achieve the following objectives. (i) to establish the causes of increased indulgence in substance abuse in Ntselamanzi village, Eastern Cape. (ii) to identify the various kinds of drugs abused by the society of Ntselamanzi (iii) to identify the consequences of substance abuse to the lives of the out-of-school youth. (iv) to suggest the strategies that can be used to reduce substance abuse in order to enhance the youth's socio-economic growth and societal bliss. Using the quantitative method ninety-eight questionnaires were administered to the out-of-school youth in Ntselamanzi village and eighty questionnaires were returned fully answered. The major findings of the study outlined that dominating factors of substance abuse in Ntselamanzi village were family drug use, increased drug accessibility, lack of recreation and peer influence.