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The implementation of a process based management system is challenging for many organizations accustomed to traditional, non-integrated, non-process based approaches to management systems. This publication provides practical guidance to nuclear organizations that are planning to implement a management system to comply with IAEA Safety Standards Series No.GS-R-3. It will also be beneficial for newcomer countries, since a vendor-provided management system delivered with a nuclear power plant to ensure safe operation is often a quality management system for operations and maintenance, which may integrate aspects related to safety and environmental protection. These quality assurance systems have to undergo a transition to a process based management system to ensure that the processes of the owner/operator will be tailored to achieve the goals and objectives for safe operation.