Anilkumar Shinde, Harinath More

DEVELOPMENT OF LORNXICAM MICROSPONGES GEL FOR TOPICAL APPLICATION

LORNXICAM MICROSPONGES GEL

• Broschiertes Buch

Produktbeschreibung

The aim of the present study was to prepare microsponges gel formulation containing lornixicam by quasi emulsion solvent diffusion method. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges were spherical, uniform in shape, between 19 to 136mim in diameter. The production yield, actual drug content and encapsulation efficiency was found in the range of 57.14±0.47 to 88.57±0.799%, 54.78±0.76 to 83.55±0.65%, and 65.73±0.35 % to 95.04±0.42 respectively. The results of compatibility studies FTIR, PXRD, DSC and accelerated stability studies showed that no chemical interaction with drug and excipients. The dermal observation of skin irritation study shows no sign of either erythema or edema after 24 hrs of application. In % inhibition was more in microsponges gel as compare with pure drug gel in anti- inflammatory activity. Formulation of lornoxicam microsponges provides better control over release of drug. This study presents a new approach based on microsponge drug delivery system for topical application.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 108
• Erscheinungstermin: 1. April 2020
• Englisch
• Abmessung: 220mm x 150mm x 7mm
• Gewicht: 179g
• ISBN-13: 9786202519199
• ISBN-10: 6202519193
• Artikelnr.: 59347250

Autorenporträt

Dr. Anilkumar J. Shinde, M.Pharm Ph.D (Farmácia) da Universidade Shivaji, Kolhapur. Tem 26 anos de experiência em marketing, ensino e investigação. Atualmente, trabalha como Professor Associado no Departamento de Farmácia da Faculdade de Farmácia Bharati Vidyapeeth, Kolhapur. Tem 64 trabalhos de investigação, 5 artigos de revisão e 2 patentes publicadas.